Epidermal growth factor receptor (EGFR, also known as HER1) and HER2, prominent
members of receptor tyrosine kinase (RTK) superfamily, have been reported as diagnostic or …

An array of some new N-(substituted)-2-((4-oxo-3-(4-sulfamoylphenyl)-3, 4-dihydrobenzo [g]
quinazolin-2-yl) thio) acetamide 5–19 were synthesized from the starting compound 4-(2 …

Introduction Epidermal growth factor receptor (EGFR) regulates several cell functions which
include cell growth, survival, multiplication, differentiation, and apoptosis. Currently, EGFR …

Deregulation of many kinases is directly linked to cancer development and the tyrosine
kinase family is one of the most important targets in current cancer therapy regimens. In this …

Two series of thiazolidinone derivatives designing for potential EGFR and HER-2 kinase
inhibitors have been discovered. Some of them exhibited significant EGFR and HER-2 …

Two new series of diethyl 2-[2-(substituted-2-oxo-1, 2-dihydroquinolin-4-yl) hydrazono]-
succinates 6a-g and 1-(2-oxo-1, 2-dihydroquinolin-4-yl)-1H-pyrazoles 7a-f have been …

A series of pyrazolyl-thiazolinone derivatives (E1–E36) have been designed and
synthesized and their biological activities were also evaluated as potential EGFR and HER …

A series of novel pyrazole-nitroimidazole derivatives had been arranged and evaluated for
their EGFR/HER-2 tyrosine kinase inhibitory activity as well as their antiproliferative …

Heterocyclic rings such as thiazole and benzimidazole are considered as privileged
structures, since they constitute several FDA-approved drugs for cancer treatment. In this …

The present study describes the synthesis of 6-bromo-2-(pyridin-3-yl)-4-substituted
quinazolines starting from 4-chloro derivative VI via the reaction with either phenolic …