Genetic evolution that occurs during cancer progression enables tumour heterogeneity,
thereby fostering tumour adaptation, therapeutic resistance and metastatic potential …

Cancer immunoediting is the process whereby immune cells protect against cancer
formation by sculpting the immunogenicity of developing tumors. Although the full process …

Cancer immunoediting explains the dual role by which the immune system can both
suppress and/or promote tumor growth. Although cancer immunoediting was first …

Accumulated data from animal models and human cancer patients strongly support the
concept that the immune system can identify and control nascent tumor cells in a process …

Publisher Summary This chapter provides an overview of how diverse mechanisms of
immunoediting preserve positive features of the immune stromal environment that facilitate …

Understanding how the immune system affects cancer development and progression has
been one of the most challenging questions in immunology. Research over the past two …

The cancer immunoediting hypothesis postulates a dual role of the immune system:
protecting the host by eliminating tumor cells, and shaping the tumor by editing its genome …

Anticancer immunotherapies involving the use of immune-checkpoint inhibitors or adoptive
cellular transfer have emerged as new therapeutic pillars within oncology. These treatments …

Highlights•Genomics analyses to identify the targets of cancer immunoediting and design
personalized cancer immunotherapy.•Emerging role of innate immune cells (NK, DC …

Cancers evade the immune system through the process of cancer immunoediting. While
immune checkpoint inhibitors are effective for reactivating tumour immunity in some cancer …