Cancer treatments which include conventional chemotherapy have not proven very
successful in curing human malignancies. The failures of these treatment modalities include …

Research into cancer therapeutics has uncovered various potential medications based on
metal-containing scaffolds after the discovery and clinical applications of cisplatin as an anti …

Metallodrugs offer potential for unique mechanism of drug action based on the choice of the
metal, its oxidation state, the types and number of coordinated ligands and the coordination …

Despite the severe side effects and the emergence of drug resistance, the use of DNA-
targeting platinum drugs remains strong either alone or in a combination chemotherapy …

Metal-based coordination compounds have been used throughout the history of human
medicine to treat various diseases, including cancer. Since the discovery of cisplatin in …

More than 99% of currently approved clinical drugs are organic compounds. In contrast, the
percentage of metal-containing drugs (metallodrugs) is very low. In cancer chemotherapy …

In the past, metal-based compounds were widely used in the treatment of disease
conditions, but the lack of clear distinction between the therapeutic and toxic doses was a …

Metal-based anticancer drugs are among the most successful therapeutic agents, as
evidenced by the frequent prescription of selected platinum and arsenic compounds to …

Metal complexes in cancer therapy have attracted much interest mainly because metals
exhibit unique characteristics, such as redox activity, metal‐ligand interaction, structure and …

Highlights•Rational design of Pt IV prodrugs to reduce toxicity and resistance of clinical Pt II
drugs.•Conjugation of targeting or imaging agents to Pt IV centers.•Multinuclear Pt II …