Interactions between hypoxic and hypercapnic signaling pathways, expressed as ventilatory
changes occurring during and following a simultaneous hypoxic-hypercapnic gas challenge …

Rats reared in hyperoxia hypoventilate in normoxia and exhibit progressive blunting of the
hypoxic ventilatory response, changes which are at least partially attributed to abnormal …

Arterial pCO2 elevations increase minute ventilation via activation of chemosensors within
the carotid body (CB) and brainstem. Although the roles of CB chemoafferents in the …

Acutely lowering ambient O2 tension increases ventilation in many mammalian species,
including humans and mice. Inheritance patterns among kinships and between mouse …

In juvenile rats, the carotid body (CB) is the primary sensor of oxygen (O2) and a secondary
sensor of carbon dioxide (CO2) in the blood. The CB communicates to the respiratory …

Ventilatory responses to hypoxia vary widely depending on the pattern and length of hypoxic
exposure. Acute, prolonged, or intermittent hypoxic episodes can increase or decrease …

Indeed, specific genes in humans and mice regulate breathing pattern at baseline and
breathing control during chemical stimulation. The current review addresses the question of …

Exposure to chronic sustained hypoxia (SH), as experienced in high altitudes, elicits an
increase in ventilation, named ventilatory acclimatization to hypoxia (VAH). We previously …

A negative influence of central chemosensitivity on peripheral chemoreflex response has
been demonstrated recently in a decerebrate-vagotomized rat preparation in situ with …

The aim of this study was to compare the ventilatory responses of C57BL6 female and male
mice during a 15min exposure to a hypoxic–hypercapnic (H–H) or a hypoxic (10% O2, 90 …