Chlamydia trachomatis infection induces inflammatory pathologies in the upper genital tract,
potentially leading to ectopic pregnancy and infertility in the affected women. Caspase-1 is …

Chlamydia trachomatis infection is associated with severe Fallopian tube tissue damage
leading to tubal infertility and ectopic pregnancy. To explore the molecular mechanisms …

Inflammasomes have been extensively characterized in monocytes and macrophages, but
not in epithelial cells, which are the preferred host cells for many pathogens. Here we show …

Intracellular persistence of Chlamydia trachomatis has been implicated in the development
of chronic infection that can result in pelvic inflammatory disease and tubal sterility. By …

The pathology observed during Chlamydia infection is due initially to localized tissue
damage caused by the infection itself, followed by deleterious host inflammatory responses …

Tubal factor infertility (TFI) represents 36% of female infertility and genital infection by
Chlamydia trachomatis (C. trachomatis) is a major cause. Although TFI is associated with …

Chlamydiae replicate in a vacuole within epithelial cells and commonly induce cell damage
and a deleterious inflammatory response of unknown molecular pathogenesis. The …

Chlamydia trachomatis infections represent the leading cause of bacterial sexually-
transmitted disease in the United States and can cause serious tissue damage leading to …

IL-1β has been implicated in the development of oviduct pathology during Chlamydia
muridarum genital infection in the mouse model. The goal of this study was to characterize …

Background Chlamydia trachomatis infection results in reproductive damage in some
women. The process and factors involved in this immunopathology are not well understood …