Curcumin analogue C66 ameliorates mouse cardiac dysfunction and structural disorders after acute myocardial infarction via suppressing JNK activation
H Hao, T Yuan, Z Li, C Zhang, J Liu, G Liang… - European Journal of …, 2023 - Elsevier
Myocardial infarction contributes to the development of cardiovascular disease, and leads to
severe inflammation and health hazards. Our previous studies identified C66, a novel …
severe inflammation and health hazards. Our previous studies identified C66, a novel …
[HTML][HTML] Curcumin analogue C66 attenuates obesity-induced myocardial injury by inhibiting JNK-mediated inflammation
L Ye, X Chen, M Wang, L Jin, Z Zhuang, D Yang… - Biomedicine & …, 2021 - Elsevier
Obesity has been recognized as a major risk factor for the development of chronic
cardiomyopathy, which is associated with increased cardiac inflammation, fibrosis, and …
cardiomyopathy, which is associated with increased cardiac inflammation, fibrosis, and …
Cardioprotective effects of the novel curcumin analogue C66 in diabetic mice is dependent on JNK 2 inactivation
C Li, X Miao, Y Lou, Z Lu, BK Adhikari… - Journal of cellular …, 2018 - Wiley Online Library
Aim Diabetic cardiomyopathy is an independent cardiac injury that can develop in diabetic
individuals. Our previous study showed that C66, a curcumin analogue, protects against …
individuals. Our previous study showed that C66, a curcumin analogue, protects against …
Inhibition of JNK phosphorylation by a novel curcumin analog prevents high glucose–induced inflammation and apoptosis in cardiomyocytes and the development of …
Hyperglycemia-induced inflammation and apoptosis have important roles in the
pathogenesis of diabetic cardiomyopathy. We recently found that a novel curcumin …
pathogenesis of diabetic cardiomyopathy. We recently found that a novel curcumin …
[HTML][HTML] Tetrahydrocurcumin improves lipopolysaccharide-induced myocardial dysfunction by inhibiting oxidative stress and inflammation via JNK/ERK signaling …
H Zhu, L Zhang, H Jia, L Xu, Y Cao, M Zhai, K Li, L Xia… - Phytomedicine, 2022 - Elsevier
Background: Acute myocardial dysfunction in patients with sepsis is attributed to oxidative
stress, inflammation, and cardiomyocyte loss; however, specific drugs for its prevention are …
stress, inflammation, and cardiomyocyte loss; however, specific drugs for its prevention are …
[HTML][HTML] Curcumin analog JM-2 alleviates diabetic cardiomyopathy inflammation and remodeling by inhibiting the NF-κB pathway
M Wang, L Jin, Q Zhang, W Zhu, H He, S Lou… - Biomedicine & …, 2022 - Elsevier
Cardiac inflammation is an important pathological process in diabetic cardiomyopathy
(DCM). Curcumin is a natural compound found in the rhizome of Curcuma longa and has …
(DCM). Curcumin is a natural compound found in the rhizome of Curcuma longa and has …
[HTML][HTML] Application of a novel curcumin analog in the management of diabetic cardiomyopathy
J Ren, JR Sowers - Diabetes, 2014 - ncbi.nlm.nih.gov
Diabetes mellitus is becoming an epidemic health threat and represents one of the most
prevalent chronic noncommunicable disorders. Cardiovascular complications are …
prevalent chronic noncommunicable disorders. Cardiovascular complications are …
A newly designed curcumin analog Y20 mitigates cardiac injury via anti-inflammatory and anti-oxidant actions in obese rats
Y Qian, P Zhong, D Liang, Z Xu, M Skibba, C Zeng… - PLoS …, 2015 - journals.plos.org
Obesity is strongly associated with the cause of structural and functional changes of the
heart in both human and animal models. Oxidative stress and inflammation play a critical …
heart in both human and animal models. Oxidative stress and inflammation play a critical …
Curcumin Ameliorates Cardiac Fibrosis by Regulating Macrophage-Fibroblast Crosstalk via IL18-P-SMAD2/3 Signaling Pathway Inhibition
J Zhao, Y Chen, Q Chen, T Hong, Z Zhong… - Frontiers in …, 2022 - frontiersin.org
Ethnopharmacological relevance: Curcumin is a bright yellow chemical produced by plants
of the Curcuma longa species. Chemically, curcumin is a diarylheptanoid, belonging to the …
of the Curcuma longa species. Chemically, curcumin is a diarylheptanoid, belonging to the …
Anti‐Inflammatory Effect of Curcumin on the Mouse Model of Myocardial Infarction through Regulating Macrophage Polarization
S Yan, M Zhou, X Zheng, Y Xing, J Dong… - Mediators of …, 2021 - Wiley Online Library
Inflammation causes tissue damage and promotes ventricular remodeling after myocardial
infarction (MI), and the infiltration and polarization of macrophages play an important role in …
infarction (MI), and the infiltration and polarization of macrophages play an important role in …
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