Comparative Genomic Hybridization (CGH) in Genotoxicology
A Baumgartner, V Hartleb, JD Taylor - Genotoxicity Assessment: Methods …, 2019 - Springer
In the past two decades, comparative genomic hybridization (CGH) and array CGH have
become indispensable tools in clinical diagnostics and toxicological risk assessment …
become indispensable tools in clinical diagnostics and toxicological risk assessment …
Comparative genomic hybridization (CGH) in genotoxicology
A Baumgartner - Genotoxicity Assessment: Methods and Protocols, 2013 - Springer
In the past two decades comparative genomic hybridization (CGH) and array CGH have
become crucial and indispensable tools in clinical diagnostics. Initially developed for the …
become crucial and indispensable tools in clinical diagnostics. Initially developed for the …
The promise of toxicogenomics for genetic toxicology: past, present and future
R David - Mutagenesis, 2020 - academic.oup.com
Toxicogenomics, the application of genomics to toxicology, was described as 'a new era'for
toxicology. Standard toxicity tests typically involve a number of short-term bioassays that are …
toxicology. Standard toxicity tests typically involve a number of short-term bioassays that are …
Inter-and intra-laboratory study to determine the reproducibility of toxicogenomics datasets
DJ Scott, AS Devonshire, YA Adeleye, ME Schutte… - Toxicology, 2011 - Elsevier
The application of toxicogenomics as a predictive tool for chemical risk assessment has
been under evaluation by the toxicology community for more than a decade. However, it …
been under evaluation by the toxicology community for more than a decade. However, it …
Sources of Variability in Toxicogenomic Assays
K Thompson, PS Pine… - … : A Powerful Tool for …, 2008 - Wiley Online Library
New technologies for simultaneous high-throughput measurement of the relative levels of
expressed transcripts provide increased molecular endpoints for toxicity assessments …
expressed transcripts provide increased molecular endpoints for toxicity assessments …
Application of toxicogenomic technology for the improvement of risk assessment
MS Hwang, EK Yoon, JY Kim, BK Son… - Molecular & cellular …, 2008 - koreascience.kr
Recently, there has been scientific discussion on the utility of-omics techniques such as
genomics, proteomics, and metabolomics within toxicological research and mechanism …
genomics, proteomics, and metabolomics within toxicological research and mechanism …
DNA microarrays as a tool in toxicogenomics
F Longueville, V Bertholet… - … Chemistry & High …, 2004 - ingentaconnect.com
Toxicogenomics is an emerging technology that defines the use of novel genomic
techniques to investigate the adverse effects of xenobiotic on gene expression …
techniques to investigate the adverse effects of xenobiotic on gene expression …
Current and future use of genomics data in toxicology: opportunities and challenges for regulatory applications
AK Goetz, BP Singh, M Battalora, JM Breier… - Regulatory Toxicology …, 2011 - Elsevier
Toxicogenomics is the application of toxicology, genetics, molecular biology and
environmental health to describe the response of organisms to environmental stimuli. The …
environmental health to describe the response of organisms to environmental stimuli. The …
Development of a toxicogenomics signature for genotoxicity using a dose‐optimization and informatics strategy in human cells
HH Li, DR Hyduke, R Chen, P Heard… - Environmental and …, 2015 - Wiley Online Library
The development of in vitro molecular biomarkers to accurately predict toxicological effects
has become a priority to advance testing strategies for human health risk assessment. The …
has become a priority to advance testing strategies for human health risk assessment. The …
Mechanistic Toxicogenomics: Design and Analysis of Microarray Experiments
K Meyer, S Schwenke… - … : A Powerful Tool for …, 2008 - Wiley Online Library
Mechanistic toxicogenomics, the elucidation of the underlying mechanisms of an observed
toxicity at the transcriptional level, has become an accepted tool in exploratory toxicology …
toxicity at the transcriptional level, has become an accepted tool in exploratory toxicology …