Pulmonary surfactant metabolism in the alveolar airspace: Biogenesis, extracellular conversions, recycling

B Olmeda, M Martínez-Calle, J Pérez-Gil - Annals of Anatomy …, 2017 - Elsevier
Pulmonary surfactant is a lipid–protein complex that lines and stabilizes the respiratory
interface in the alveoli, allowing for gas exchange during the breathing cycle. At the same …

[HTML][HTML] Pulmonary surfactant: functions and molecular composition

J Goerke - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 1998 - Elsevier
This review briefly notes recent findings important for understanding the surface mechanical
functions of pulmonary surfactant. Currently known surfactant-specific proteins and lipids are …

[HTML][HTML] Structure-function relationships in pulmonary surfactant membranes: from biophysics to therapy

E Lopez-Rodriguez, J Pérez-Gil - Biochimica et Biophysica Acta (BBA) …, 2014 - Elsevier
Pulmonary surfactant is an essential lipid–protein complex to maintain an operative
respiratory surface at the mammalian lungs. It reduces surface tension at the alveolar air …

Pulmonary surfactants and their role in pathophysiology of lung disorders

A Akella, SB Deshpande - 2013 - nopr.niscpr.res.in
Surfactant is an agent that decreases the surface tension between two media. The surface
tension between gaseous-aqueous interphase in the lungs is decreased by the presence of …

Pulmonary surfactant pathophysiology: current models and open questions

J Perez-Gil, TE Weaver - Physiology, 2010 - journals.physiology.org
Pulmonary surfactant is an essential lipid-protein complex that stabilizes the respiratory units
(alveoli) involved in gas exchange. Quantitative or qualitative derangements in surfactant …

The closer we look the more we see? Quantitative microscopic analysis of the pulmonary surfactant system

M Ochs - Cellular Physiology and Biochemistry, 2009 - karger.com
The surfactant system of the lung has essential biophysical and immunomodulatory
functions. Only at the electron microscopic level does surfactant reveal its morphological …

Pulmonary surfactant in health and human lung diseases: state of the art

M Griese - European Respiratory Journal, 1999 - Eur Respiratory Soc
Pulmonary surfactant is a complex and highly surface active material composed of lipids and
proteins which is found in the fluid lining the alveolar surface of the lungs. Surfactant …

Synthesis of surfactant lipids in the adult lung

LMG Van Golde - Annual review of physiology, 1985 - annualreviews.org
Pulmonary surfactant prevents alveoli from collapsing at low lung volumes by reducing the
surface tension at the alveolar surface. Surfactant deficiency or abnormality occurs, for …

[HTML][HTML] Structure of pulmonary surfactant membranes and films: the role of proteins and lipid–protein interactions

J Pérez-Gil - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2008 - Elsevier
The pulmonary surfactant system constitutes an excellent example of how dynamic
membrane polymorphism governs some biological functions through specific lipid–lipid …

Synthesis and assembly of lung surfactant

HP Haagsman, LMG Van Golde - Annual review of physiology, 1991 - annualreviews.org
The alveolar surfaces of the lungs are lined with a complex and highly surface-active
material: pulmonary surfactant. This material consists of about 90% lipids and 5-10 …