Network pharmacology, molecular docking-driven, Qbd-Engineered antifungal in-situ gel loaded with voriconazole nanostructured lipid carriers

A Tiwari, V Tiwari, B Palaria, R Aslam… - Journal of …, 2023 - Taylor & Francis
Fungal infections (FIs) affect majority of the population, but the current treatments face
challenges in terms of their effectiveness. This study focused on specific fungal targets …

Voriconazole loaded nanostructured lipid carriers based topical delivery system: QbD based designing, characterization, in-vitro and ex-vivo evaluation

T Waghule, VK Rapalli, G Singhvi, P Manchanda… - Journal of drug delivery …, 2019 - Elsevier
Clinical investigation showed that voriconazole exhibits various adverse effects such as
nausea, vomiting, and other gastric disturbances. To overcome these associated side …

Development and optimization of luliconazole nanostructured lipid carriers based gel by quality by design its skin distribution studies, dermatokinetic modeling & in …

E Bhargav, YP Reddy, KB Koteshwara - Current Drug Delivery, 2021 - ingentaconnect.com
Aim: The present study was aimed to improve the permeability of Luliconazole (LZ) and to
localize high drug concentrations at skin layers by Quality by Design (QbD) based …

QbD-Driven Development and Characterization of Solid Lipid Nanoparticles (SLNs)–Based Nanogel of Luliconazole for the Effective Management of Dermal Fungal …

G Khurana, VV Sharma, D Arora - Journal of Pharmaceutical Innovation, 2023 - Springer
Abstract Purpose Solid lipid nanoparticles (SLNs) have shown tremendous utility in the
topical delivery of such anti-fungal moieties. Hence, it was aimed to develop luliconazole …

Formulation and molecular docking simulation study of luliconazole nanosuspension–based nanogel for transdermal drug delivery using modified polymer

MS Shaikh, MA Kale - Materials Today Chemistry, 2020 - Elsevier
The purpose of study was to formulate nanosuspension-based nanogel of luliconazole (LLZ)
for transdermal delivery to enhance its skin retention and effectiveness using modified starch …

Enhanced antifungal activity of voriconazole-loaded nanostructured lipid carriers against Candida albicans with a dimorphic switching model

B Tian, Q Yan, J Wang, C Ding, S Sai - International Journal of …, 2017 - Taylor & Francis
Candida commonly adheres to implanted medical devices and forms biofilms. Due to the
minimal activity of current antifungals against biofilms, new drugs or drug-delivery systems to …

Dermatokinetic assessment of luliconazole-loaded nanostructured lipid carriers (NLCs) for topical delivery: QbD-driven design, optimization, and in vitro and ex vivo …

A Mahmood, VK Rapalli, S Gorantla, T Waghule… - Drug Delivery and …, 2022 - Springer
The present study is concerned with the QbD-based design and development of
luliconazole-loaded nanostructured lipid carriers (NLCs) hydrogel for enhanced skin …

Limonene-Enriched Ultra-Structural Cubosomes to Augment Ocular Delivery of a Poorly Water Soluble Anti-Fungal Drug: Fabrication, Characterization, Statistical …

AA Nemr, S Ahmed, IM Adel - Journal of Drug Delivery Science and …, 2024 - Elsevier
The target of this investigation was to obtain the composition of the optimized Fenticonazole
nitrate (FCN)-loaded cubosomal formula that can prolong precorneal retention, increase …

Luliconazole loaded lyotropic liquid crystalline nanoparticles for topical delivery: QbD driven optimization, in-vitro characterization and dermatokinetic assessment

A Mahmood, VK Rapalli, T Waghule, S Gorantla… - Chemistry and physics …, 2021 - Elsevier
Fungal infections are an important cause of morbidity and pose a serious health concern
especially in immunocompromised patients. Luliconazole (LUL) is a topical imidazole …

[PDF][PDF] Design and assessment of in silico screened diosmin incorporated ultra-flexible topical lipid gel system for the treatment of varicose vein

A Dubey, A Shetty, CR Shetty, N Dhas… - Journal of Applied …, 2024 - japsonline.com
The ultra-flexible lipid gel system (UFLGS) consists of bilayer lipid membranes, responsible
for highly elastic and deformable vesicles compared to conventional topical systems …