Tyrosine kinase gene rearrangements in epithelial malignancies
Chromosomal rearrangements that lead to oncogenic kinase activation are observed in
many epithelial cancers. These cancers express activated fusion kinases that drive the …
many epithelial cancers. These cancers express activated fusion kinases that drive the …
Fusions in solid tumours: diagnostic strategies, targeted therapy, and acquired resistance
Structural gene rearrangements resulting in gene fusions are frequent events in solid
tumours. The identification of certain activating fusions can aid in the diagnosis and effective …
tumours. The identification of certain activating fusions can aid in the diagnosis and effective …
Novel Targets in Non‐Small Cell Lung Cancer: ROS1 and RET Fusions
JF Gainor, AT Shaw - The oncologist, 2013 - academic.oup.com
The discovery of chromosomal rearrangements involving the anaplastic lymphoma kinase
(ALK) gene in non‐small cell lung cancer (NSCLC) has stimulated renewed interest in …
(ALK) gene in non‐small cell lung cancer (NSCLC) has stimulated renewed interest in …
ROS1 and ALK Fusions in Colorectal Cancer, with Evidence of Intratumoral Heterogeneity for Molecular Drivers
DL Aisner, TT Nguyen, DD Paskulin, AT Le… - Molecular Cancer …, 2014 - AACR
Activated anaplastic lymphoma kinase (ALK) and ROS1 tyrosine kinases, through gene
fusions, have been found in lung adenocarcinomas and are highly sensitive to selective …
fusions, have been found in lung adenocarcinomas and are highly sensitive to selective …
RET, ROS1 and ALK fusions in lung cancer
K Takeuchi, M Soda, Y Togashi, R Suzuki, S Sakata… - Nature medicine, 2012 - nature.com
Through an integrated molecular-and histopathology-based screening system, we
performed a screening for fusions of anaplastic lymphoma kinase (ALK) and c-ros oncogene …
performed a screening for fusions of anaplastic lymphoma kinase (ALK) and c-ros oncogene …
Entrectinib, a Pan–TRK, ROS1, and ALK inhibitor with activity in multiple molecularly defined cancer indications
E Ardini, M Menichincheri, P Banfi, R Bosotti… - Molecular cancer …, 2016 - AACR
Activated ALK and ROS1 tyrosine kinases, resulting from chromosomal rearrangements,
occur in a subset of non–small cell lung cancers (NSCLC) as well as other tumor types and …
occur in a subset of non–small cell lung cancers (NSCLC) as well as other tumor types and …
[HTML][HTML] Beyond ALK and ROS1: RET, NTRK, EGFR and BRAF gene rearrangements in non-small cell lung cancer
AF Farago, CG Azzoli - Translational Lung Cancer Research, 2017 - ncbi.nlm.nih.gov
The discovery of gene rearrangements involving the receptor tyrosine kinase genes ALK
and ROS1 has revolutionized management of the subset of non-small cell lung cancers …
and ROS1 has revolutionized management of the subset of non-small cell lung cancers …
Differential subcellular localization regulates oncogenic signaling by ROS1 kinase fusion proteins
DS Neel, DV Allegakoen, V Olivas, MK Mayekar… - Cancer research, 2019 - AACR
Chromosomal rearrangements involving receptor tyrosine kinases (RTK) are a clinically
relevant oncogenic mechanism in human cancers. These chimeric oncoproteins often …
relevant oncogenic mechanism in human cancers. These chimeric oncoproteins often …
Tyrosine kinase gene fusions in cancer: translating mechanisms into targeted therapies
S Medves, JB Demoulin - Journal of cellular and molecular …, 2012 - Wiley Online Library
Introduction• Tyrosine kinase inhibitors• Fusion gene structure and expression• Loss of wild‐
type alleles• Oligomerization triggers TK activation• Inhibitory domain deletion• Signalling …
type alleles• Oligomerization triggers TK activation• Inhibitory domain deletion• Signalling …
Anaplastic lymphoma kinase fusions: Roles in cancer and therapeutic perspectives
Z Cao, Q Gao, M Fu, NAN Ni, Y Pei… - Oncology …, 2019 - spandidos-publications.com
Receptor tyrosine kinase (RTK) anaplastic lymphoma kinase (ALK) serves a crucial role in
brain development. ALK is located on the short arm of chromosome 2 (2p23) and exchange …
brain development. ALK is located on the short arm of chromosome 2 (2p23) and exchange …