Chromosomal rearrangements that lead to oncogenic kinase activation are observed in
many epithelial cancers. These cancers express activated fusion kinases that drive the …

Structural gene rearrangements resulting in gene fusions are frequent events in solid
tumours. The identification of certain activating fusions can aid in the diagnosis and effective …

The discovery of chromosomal rearrangements involving the anaplastic lymphoma kinase
(ALK) gene in non‐small cell lung cancer (NSCLC) has stimulated renewed interest in …

Activated anaplastic lymphoma kinase (ALK) and ROS1 tyrosine kinases, through gene
fusions, have been found in lung adenocarcinomas and are highly sensitive to selective …

Through an integrated molecular-and histopathology-based screening system, we
performed a screening for fusions of anaplastic lymphoma kinase (ALK) and c-ros oncogene …

Activated ALK and ROS1 tyrosine kinases, resulting from chromosomal rearrangements,
occur in a subset of non–small cell lung cancers (NSCLC) as well as other tumor types and …

The discovery of gene rearrangements involving the receptor tyrosine kinase genes ALK
and ROS1 has revolutionized management of the subset of non-small cell lung cancers …

Chromosomal rearrangements involving receptor tyrosine kinases (RTK) are a clinically
relevant oncogenic mechanism in human cancers. These chimeric oncoproteins often …

Introduction• Tyrosine kinase inhibitors• Fusion gene structure and expression• Loss of wild‐
type alleles• Oligomerization triggers TK activation• Inhibitory domain deletion• Signalling …

Receptor tyrosine kinase (RTK) anaplastic lymphoma kinase (ALK) serves a crucial role in
brain development. ALK is located on the short arm of chromosome 2 (2p23) and exchange …