Background One of the central physiological functions of the lungs is to transfer inhaled
gases from the alveoli to pulmonary capillary blood. However, current measures of alveolar …

By permitting direct visualization of the airspaces of the lung, magnetic resonance imaging
(MRI) using hyperpolarized gases provides unique strategies for evaluating pulmonary …

Hyperpolarized 129Xe MRI has emerged as a novel means to evaluate pulmonary function
via 3D mapping of ventilation, interstitial barrier uptake, and RBC transfer. However, the …

Clinical magnetic resonance imaging of the lung is technologically challenging, yet over the
past two decades hyperpolarized noble gas (3He and 129Xe) imaging has demonstrated …

Purpose To demonstrate the feasibility of mapping gas exchange with single breath‐hold
hyperpolarized (HP) 129Xe in humans, acquiring parametric maps of lung physiology. The …

The majority of researchers investigating hyperpolarized gas MRI as a candidate functional
lung imaging modality have used 3He as their imaging agent of choice rather than 129Xe …

Hyperpolarized (HP) 129Xe MRI uniquely images pulmonary ventilation, gas exchange, and
terminal airway morphology rapidly and safely, providing novel information not possible …

Effective pulmonary gas exchange relies on the free diffusion of gases across the thin tissue
barrier separating airspace from the capillary red blood cells (RBCs). Pulmonary …

Background MRI of hyperpolarized 129Xenon (HP 129Xe) is increasingly utilized for
investigating pulmonary function. The solubility of HP 129Xe in lung tissue, blood plasma …

Despite a myriad of technical advances in medical imaging, as well as the growing need to
address the global impact of pulmonary diseases, such as asthma and chronic obstructive …