Hypermethylation of CpG islands located in the promoter regions of genes is a major event
in the development of the majority of cancer types, due to the subsequent aberrant silencing …

The potential anti-senescence gene Klotho (KL) has been recently found to participate in the
progression of several different human cancers including breast, lung, and cervical cancer …

As one of major epigenetic changes to inactivate tumor suppressor genes in human
carcinogenesis, promoter hypermethylation was proposed as a marker to define novel tumor …

ABSTRACT KLOTHO was originally identified as an aging-suppressor gene that causes a
human aging-like phenotype when tested in KLOTHO-deficient-mice. Recent evidence …

Klotho is identified as a tumor suppressor in several tumors, but the expression of the Klotho
gene (KL) and its regulative mechanism are not reported in hepatocellular carcinoma …

Abstract Background The Klotho gene was originally identified as an anti-aging gene in
1997. Recent studies have demonstrated aberrant expression of Klotho in a number of …

Several intracellular metabolic pathways in which multiple genes have a role affect the
aging process. One important genetic factor associated with aging is klotho gene. In some …

Carcinoma follows a course of multiple changes that are affected by several important
factors, with epigenetic silencing of the promoter gene being one of them. A series of studies …

Aberrant DNA methylation at CpG islands has been implicated as a critical player in
colorectal cancer (CRC). However, its biological role and clinical significance in …

Colorectal cancer is the most common type of gastrointestinal cancer in the world. Klotho is
an anti-aging glycosylated transmembrane protein that plays an important role in regulating …