Abstract The Gs-coupled A2A adenosine receptor (A2AAR) has been explored extensively
as a pharmaceutical target, which has led to numerous clinical trials. However, only one …

In the past decades, many efforts were undertaken to develop ligands for the adenosine
receptors, with the purpose to individuate agonists and antagonists affinity and selectivity for …

Since the discovery of the biological effects of adenosine, the development of potent and
selective agonists and antagonists of adenosine receptors has been the subject of medicinal …

The adenosine A2A receptor is a G-protein-coupled receptor (GPCR) that has been
extensively studied during the past few decades because it offers numerous possibilities for …

Although significant progress has been made in the past few decades demonstrating that
adenosine modulates a variety of physiological and pathophysiological processes through …

The adenosine A2A receptor is a member of the G protein-coupled receptor family and
mediates multiple physiological effects of adenosine, both at the central nervous system and …

Introduction: Adenosine exerts its effects by interacting with G-protein coupled receptors
(GPCR) namely A1, A2A, A2B and A3, respectively. These are involved in several diseases …

The development of potent and selective agonists and antagonists of adenosine receptors
(ARs) has been a target of medicinal chemistry research for several decades, and recently …

The A2A adenosine receptor (A2AAR) plays critical roles in human physiology and
pathophysiology, which makes it an important drug target. Previous drug-discovery efforts …

The A3 adenosine receptors (A3 ARs), belonging to the adenosine receptor family of G-
protein-coupled receptors (GPCRs), are ubiquitously expressed in a wide variety of tissues …