Lysine‐specific demethylase 1 aggravated oxidative stress and ferroptosis induced by renal ischemia and reperfusion injury through activation of TLR4/NOX4 …
R Feng, Y Xiong, Y Lei, Q Huang, H Liu… - Journal of Cellular …, 2022 - Wiley Online Library
Acute kidney injury (AKI) is mainly caused by renal ischaemia reperfusion injury (IRI). Lots of
evidence suggests that ferroptosis and oxidative stress play the vital role in renal IRI …
evidence suggests that ferroptosis and oxidative stress play the vital role in renal IRI …
METTL3 contributes to renal ischemia-reperfusion injury by regulating Foxd1 methylation
F Meng, Y Liu, Q Chen, Q Ma, S Gu… - American Journal …, 2020 - journals.physiology.org
To investigate the mechanism of renal ischemia-reperfusion injury (IRI) via regulation of N 6-
methyl-adenosine (m6A) and relevant genes, IRI was induced in Sprague-Dawley rats, and …
methyl-adenosine (m6A) and relevant genes, IRI was induced in Sprague-Dawley rats, and …
Lysine-specific demethylase 1 induced epithelial–mesenchymal transition and promoted renal fibrosis through Jagged-1/Notch signaling pathway
H Zhang, J Xing, L Zhao - Human & experimental toxicology, 2021 - journals.sagepub.com
Objective TGF-β1-induced excessive deposition of extracellular matrix (ECM) and epithelial-
mesenchymal transition (EMT) process of tubular epithelial cells play critical roles in the …
mesenchymal transition (EMT) process of tubular epithelial cells play critical roles in the …
USP7 accelerates FMR1-mediated ferroptosis by facilitating TBK1 ubiquitination and DNMT1 deubiquitination after renal ischemia–reperfusion injury
B Dong, C Ding, H Xiang, J Zheng, X Li, W Xue… - Inflammation …, 2022 - Springer
Background Renal ischemia/reperfusion (I/R) leads to acute kidney injury and is associated
with cell ferroptosis, an oxidative programmed cell death. This study aims to explore whether …
with cell ferroptosis, an oxidative programmed cell death. This study aims to explore whether …
Dexmedetomidine Attenuates Ferroptosis-Mediated Renal Ischemia/Reperfusion Injury and Inflammation by Inhibiting ACSL4 via α2-AR
W Tao, X Shan, J Zhang, H Liu, B Wang… - Frontiers in …, 2022 - frontiersin.org
Ischemia-reperfusion (I/R) injury is a serious clinical pathology associated with acute kidney
injury (AKI). Ferroptosis is non-apoptotic cell death that is known to contribute to renal I/R …
injury (AKI). Ferroptosis is non-apoptotic cell death that is known to contribute to renal I/R …
[HTML][HTML] METTL3-mediated N6-methyladenosine modification stimulates mitochondrial damage and ferroptosis of kidney tubular epithelial cells following acute kidney …
C Hu, B Zhang, S Zhao - European Journal of Medicinal Chemistry, 2023 - Elsevier
Abstract N6-methyladenosine (m 6 A) and MELLT3 assume a role in the development of
acute kidney injury (AKI). However, their mechanism in AKI remains under-explored. On this …
acute kidney injury (AKI). However, their mechanism in AKI remains under-explored. On this …
The histone demethylase LSD1 promotes renal inflammation by mediating TLR4 signaling in hepatitis B virus-associated glomerulonephritis
YT Yang, X Wang, YY Zhang, WJ Yuan - Cell Death & Disease, 2019 - nature.com
Renal inflammation significantly contributes to the progression of hepatitis B virus (HBV)-
associated glomerulonephritis (HBV-GN), but the mechanisms that control its precise …
associated glomerulonephritis (HBV-GN), but the mechanisms that control its precise …
[HTML][HTML] ACSL4 deficiency confers protection against ferroptosis-mediated acute kidney injury
Y Wang, M Zhang, R Bi, Y Su, F Quan, Y Lin, C Yue… - Redox biology, 2022 - Elsevier
The term ferroptosis coined in 2012 causes acute kidney injury (AKI). However, its pathway
mechanism in AKI is poorly understood. In this study, we conducted an RNA-sequence …
mechanism in AKI is poorly understood. In this study, we conducted an RNA-sequence …
Molecular mechanism of NR4A1/MDM2/P53 signaling pathway regulation inducing ferroptosis in renal tubular epithelial cells involved in the progression of renal …
G Lin, H Jiang, Z Zhang, L Ning, W Zhang… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Revealing the possible molecular mechanism of the NR4A1 (nuclear receptor subfamily 4
group A member 1)-MDM2 (MDM2 proto-oncogene)-P53 (tumor protein p53) signaling …
group A member 1)-MDM2 (MDM2 proto-oncogene)-P53 (tumor protein p53) signaling …
Inhibition of the IRE1/JNK pathway in renal tubular epithelial cells attenuates ferroptosis in acute kidney injury
Y Liang, Z Liu, L Qu, Y Wang, Y Zhou, L Liang… - Frontiers in …, 2022 - frontiersin.org
Backgroud: Ferroptosis is a form of regulated cell death in ischemia-reperfusion (I/R) injury
models. Acute kidney injury (AKI) induced by I/R injury can result in cell death, and …
models. Acute kidney injury (AKI) induced by I/R injury can result in cell death, and …