IL-23 is a heterodimeric cytokine composed of the IL-12p40 “soluble receptor” subunit and a
novel cytokine-like subunit related to IL-12p35, termed p19. Human and mouse IL-23 exhibit …

Recent discoveries of interleukin (IL)-23, its receptor, and its signal-transduction pathway
add to our understanding of cellular immunity. IL-23 is a heterodimer, comprising IL-12 p40 …

IL-23 is a recently discovered heterodimeric cytokine that shares biological properties with
proinflammatory cytokines. The biologically active heterodimer consists of p19 and the p40 …

With the use of a partial sequence of the human genome, we identified a gene encoding a
novel soluble receptor belonging to the class II cytokine receptor family. This gene is …

The newly discovered cytokine interleukin (IL)-23 shares some in vivo functions with IL-12,
including the activation of the transcription factor STAT4 (signal tranducer and activator of …

Summary Interleukin-23 (IL-23), an IL-12 family cytokine, plays pivotal roles in pro-
inflammatory T helper 17 cell responses linked to autoimmune and inflammatory diseases …

IL-22 is an IL-10 homologue that binds to and signals through the class II cytokine receptor
heterodimer IL-22RA1/CRF2–4. IL-22 is produced by T cells and induces the production of …

Interleukin (IL)-17 is a pro-inflammatory cytokine that is produced by activated T cells.
Despite increasing evidence that high levels of IL-17 are associated with several chronic …

We report the identification of a novel human cytokine, distantly related to interleukin (IL)-10,
which we term IL-22. IL-22 is produced by activated T cells. IL-22 is a ligand for CRF2–4, a …

The heterodimeric cytokine IL-23 consists of a private cytokine-like p19 subunit and a
cytokine receptor-like subunit, p40, which is shared with IL-12. Previously reported IL-12p40 …