Solid tumors possess unique microenvironments that are exposed to chronic hypoxic
conditions, so-called tumor hypoxia. Although more than half a century has passed since it …

Hypoxia, defined as a decrease of tissue oxygen levels, represents a fundamental
pathophysiological condition in the microenvironment of solid tumors. Tumor hypoxia is …

Hypoxia has been recognized as one of the fundamentally important features of solid tumors
and plays a critical role in various cellular and physiologic events, including cell …

Hypoxia or low oxygen concentration in tumor microenvironment has widespread effects
ranging from altered angiogenesis and lymphangiogenesis, tumor metabolism, growth, and …

Simple Summary Hypoxia is defined as the inadequate supply of oxygen in tissues. Regions
of acute and chronic hypoxia are a universal feature of the tumor microenvironment and a …

Hypoxia is an important feature of the microenvironment of a wide range of solid tumours. Its
critical role in radio-and chemoresistance and its significance as an adverse prognostic …

Hypoxic microenvironments frequently exist in many solid tumours with oxygen levels
fluctuating temporally and spatially from normoxia to hypoxia. The response to hypoxia in …

Abstract The hypoxia-inducible factor-1 (HIF-1) is primarily involved in the sensing and
adapting of cells to changes in the O2 level, which is essential for their viability. An …

Hypoxia is an integral part of the tumor microenvironment, caused primarily due to rapidly
multiplying tumor cells and a lack of proper blood supply. Among the major hypoxic …

Hypoxia is an important phenomenon in the tumor microenvironment. Hypoxic tumors are
more aggressive and resistant to anti-neoplastic treatments. HIF-1? plays a major role in the …