Recent studies challenge the previous view that apoptosis within the granulosa cells of the
maturing ovarian follicle is a reflection of aging and consequently a marker for poor quality of …

The quality of oocytes depends on interactions with surrounding granulosa cells. Granulosa
cells are essential in normal follicular maturation process since they produce steroidal …

In the mammalian ovary, follicular development and atresia are closely regulated by cell
death and survival-promoting factors, including hormones (gonadotropins) and intraovarian …

The vertebrate ovary is an extremely dynamic organ in which excessive or defective follicles
are rapidly and effectively eliminated early in ontogeny and thereafter continuously …

BACKGROUND Regulated cell death is a fundamental component of numerous
physiological processes; spanning from organogenesis in utero, to normal cell turnover …

Cell death was first described in rabbit ovaries (Graaffian follicles), the phenomenon being
called 'chromatolysis' rather than apoptosis. In humans, the ovarian endowment of …

In each estrous cycle, only one follicle, the dominant follicle, reaches full maturation while
the other recruited follicles become atretic in a process characteristic of programmed cell …

Ovarian cell death is an essential process for the homeostasis of ovarian function in human
and other mammalian species. It ensures the selection of the dominant follicle and the …

It has become evident that the physiological removal of cells through apoptosis during
embryonic and postnatal development of multicellular organisms is a mandatory process to …

The mammalian ovary is an extremely dynamic organ in which a large majority of follicles
are effectively eliminated throughout their reproductive life. Due to the numerous efforts of …