Characterization of central inhibitory muscarinic autoreceptors by the use of muscarinic acetylcholine receptor knock-out mice
W Zhang, AS Basile, J Gomeza… - Journal of …, 2002 - Soc Neuroscience
Forebrain muscarinic acetylcholine (ACh) receptors (mAChRs; M1-M5) are predicted to play
important roles in many fundamental central functions, including higher cognitive processes …
important roles in many fundamental central functions, including higher cognitive processes …
M2 muscarinic autoreceptors modulate acetylcholine release in prefrontal cortex of C57BL/6J mouse
CL Douglas, HA Baghdoyan, R Lydic - Journal of Pharmacology and …, 2001 - ASPET
Muscarinic autoreceptors modulate cholinergic neurotransmission in animals ranging from
insects to humans. No previous studies have characterized autoreceptor modulation of …
insects to humans. No previous studies have characterized autoreceptor modulation of …
Use of M1–M5 Muscarinic Receptor Knockout Mice as Novel Tools to Delineate the Physiological Roles of the Muscarinic Cholinergic System
In this review we report recent findings on the physiological role of the five known muscarinic
acetylcholine receptors (mAChRs) as shown by gene targeting technology. Using knockout …
acetylcholine receptors (mAChRs) as shown by gene targeting technology. Using knockout …
Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development
Muscarinic acetylcholine receptors (mAChRs), M1–M5, regulate the activity of numerous
fundamental central and peripheral functions. The lack of small-molecule ligands that can …
fundamental central and peripheral functions. The lack of small-molecule ligands that can …
A subpopulation of neuronal M4 muscarinic acetylcholine receptors plays a critical role in modulating dopamine-dependent behaviors
J Jeon, D Dencker, G Wörtwein… - Journal of …, 2010 - Soc Neuroscience
Acetylcholine (ACh) regulates many key functions of the CNS by activating cell surface
receptors referred to as muscarinic ACh receptors (M1–M5 mAChRs). Like other mAChR …
receptors referred to as muscarinic ACh receptors (M1–M5 mAChRs). Like other mAChR …
M1 and M4 receptors modulate hippocampal pyramidal neurons
S Dasari, AT Gulledge - Journal of neurophysiology, 2011 - journals.physiology.org
Acetylcholine (ACh), acting at muscarinic ACh receptors (mAChRs), modulates the
excitability and synaptic connectivity of hippocampal pyramidal neurons. CA1 pyramidal …
excitability and synaptic connectivity of hippocampal pyramidal neurons. CA1 pyramidal …
Muscarinic acetylcholine receptor subtypes in cerebral cortex and hippocampus
LA Volpicelli, AI Levey - Progress in brain research, 2004 - Elsevier
Publisher Summary This chapter focuses on the muscarinic acetylcholine receptor (mAChR)
family, whose five members participate in critical cholinergic functions including learning …
family, whose five members participate in critical cholinergic functions including learning …
M 1-M 5 muscarinic receptor knockout mice as novel tools to study the physiological roles of the muscarinic cholinergic system
J Wess, A Duttaroy, W Zhang, J Gomeza… - Receptors and …, 2003 - Taylor & Francis
A large body of evidence indicates that muscarinic acetylcholine receptors (mAChRs) play
critical roles in regulating the activity of many important functions of the central and …
critical roles in regulating the activity of many important functions of the central and …
Muscarinic acetylcholine receptor expression in memory circuits: implications for treatment of Alzheimer disease
AI Levey - Proceedings of the National Academy of …, 1996 - National Acad Sciences
Cholinergic transmission at muscarinic acetylcholine receptors (mAChR) has been
implicated in higher brain functions such as learning and memory, and loss of synapses may …
implicated in higher brain functions such as learning and memory, and loss of synapses may …
A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in …
JK Shirey, AE Brady, PJ Jones, AA Davis… - Journal of …, 2009 - Soc Neuroscience
M1 muscarinic acetylcholine receptors (mAChRs) may represent a viable target for treatment
of disorders involving impaired cognitive function. However, a major limitation to testing this …
of disorders involving impaired cognitive function. However, a major limitation to testing this …