Evidence for an antagonist form of the chemokine CXCL10 in patients chronically infected with HCV

A Casrouge, J Decalf, M Ahloulay… - The Journal of …, 2011 - Am Soc Clin Investig
Chronic infection with hepatitis C virus (HCV) is a major public health problem, with nearly
170 million infected individuals worldwide. Current treatment for chronic infection is a …

[PDF][PDF] Truncated CXCL10 is associated with failure to achieve spontaneous clearance of acute hepatitis C infection

A Riva, M Laird, A Casrouge, A Ambrozaitis… - …, 2014 - Wiley Online Library
The pathogenesis of hepatitis C virus (HCV) infection is strongly influenced by the nature of
the host's antiviral immunity. Counterintuitively, elevated serum concentrations of C‐X‐C …

Immunomodulation of CXCL10 secretion by hepatitis C virus: could CXCL10 be a prognostic marker of chronic hepatitis C?

SM Ferrari, P Fallahi, I Ruffilli, G Elia… - Journal of …, 2019 - Wiley Online Library
Chemokine (C‐X‐C motif) ligand (CXCL) 10 and other CXCR3 chemokines are involved in
the pathogenesis of acute and “chronic hepatitis C virus (HCV) infection”(CHC). Here, we …

Plasma chemokine levels correlate with the outcome of antiviral therapy in patients with hepatitis C

D Butera, S Marukian, AE Iwamaye, E Hembrador… - Blood, 2005 - ashpublications.org
Chronic infection with the hepatitis C virus (HCV) is associated with failures of T-cell–
mediated immune clearance and with abnormal B-cell growth and activation. We examined …

Differential expression of the CXCR3 ligands in chronic hepatitis C virus (HCV) infection and their modulation by HCV in vitro

KJ Helbig, A Ruszkiewicz, RE Lanford… - Journal of …, 2009 - Am Soc Microbiol
To investigate chemokine expression networks in chronic hepatitis C virus (HCV) infection,
we used microarray analysis to determine chemokine expression in human infection and in …

Peripheral CXCR3-associated chemokines as biomarkers of fibrosis in chronic hepatitis C virus infection

M Zeremski, R Dimova, Q Brown… - The Journal of …, 2009 - academic.oup.com
Background CXCR3-associated chemokines CXCL9–CXCL11 promote histologic
progression in chronic hepatitis C virus (HCV) infection, as indicated by elevated …

Molecular pathways: hepatitis C virus, CXCL10, and the inflammatory road to liver cancer

J Brownell, SJ Polyak - Clinical Cancer Research, 2013 - AACR
An estimated 170 million people worldwide are chronically infected with the hepatitis C virus
(HCV), which is characterized histologically by a persistent immune and inflammatory …

Involvement of the CXCL12/CXCR4 pathway in the advanced liver disease that is associated with hepatitis C virus or hepatitis B virus

O Wald, O Pappo, R Safadi… - European journal of …, 2004 - Wiley Online Library
Chronic hepatitis C virus (HCV) and hepatitis B virus (HBV) infection is accompanied by
inflammation and fibrosis eventually leading to cirrhosis. The chemokine CXCL12 is …

The role of chemokines as inflammatory mediators in chronic hepatitis C virus infection

M Zeremski, LM Petrovic, AH Talal - Journal of viral hepatitis, 2007 - Wiley Online Library
Hepatitis C virus (HCV) is a leading cause of chronic liver disease that can progress to
cirrhosis and/or hepatocellular carcinoma. Intrahepatic inflammation and liver cell injury are …

[PDF][PDF] Proapoptotic effects of the chemokine, CXCL 10 are mediated by the noncognate receptor TLR4 in hepatocytes

H Sahin, E Borkham‐Kamphorst, NT do O… - …, 2013 - Wiley Online Library
Aberrant expression of the chemokine CXC chemokine ligand (CXCL) 10 has been linked to
the severity of hepatitis C virus (HCV)‐induced liver injury, but the underlying molecular …