Upon activation by calcineurin, the nuclear factor of activated T-cells (NFAT) translocates to
the nucleus and guides the transcription of numerous molecules involved in inflammation …

Amyloid β (Aβ) peptides, the main pathological species associated with Alzheimer's disease
(AD), disturb intracellular calcium homeostasis, which in turn activates the calcium …

Mounting evidence supports a fundamental role for Ca2+ dysregulation in astrocyte
activation. Though the activated astrocyte phenotype is complex, cell-type targeting …

Increasing evidence suggests that the calcineurin (CN)-dependent transcription factor NFAT
(Nuclear Factor of Activated T cells) mediates deleterious effects of astrocytes in progressive …

Amyloid β (Aβ)-containing plaques are surrounded by dystrophic neurites in the Alzheimer's
disease (AD) brain, but whether and how plaques induce these neuritic abnormalities …

Oligodendrocytes produce myelin for rapid transmission and saltatory conduction of action
potentials in the vertebrate central nervous system. Activation of the myelination program …

Hyperexcitable neuronal networks are mechanistically linked to the pathologic and clinical
features of Alzheimer's disease (AD). Astrocytes are a primary defense against …

The ongoing epidemics of metabolic diseases and increase in the older population have
increased the incidences of neurodegenerative diseases. Evidence from murine and cell …

Interleukin-1β (IL-1β) and the Ca 2+/calmodulin-dependent protein phosphatase,
calcineurin, have each been shown to play an important role in neuroinflammation …

Neuronal apoptosis is critical for normal development of the mammalian nervous system
and also contributes to the pathogenesis of ischemic and degenerative diseases of the …