Vaporized E-cigarette liquids induce ion transport dysfunction in airway epithelia

VY Lin, MD Fain, PL Jackson, TF Berryhill… - American journal of …, 2019 - atsjournals.org
Cigarette smoking is associated with chronic obstructive pulmonary disease and chronic
bronchitis. Acquired ion transport abnormalities, including cystic fibrosis transmembrane …

Airway epithelial cell exposure to distinct e-cigarette liquid flavorings reveals toxicity thresholds and activation of CFTR by the chocolate flavoring 2, 5-dimethypyrazine

CL Sherwood, S Boitano - Respiratory research, 2016 - Springer
Background The potential for adverse respiratory effects following exposure to electronic (e-)
cigarette liquid (e-liquid) flavorings remains largely unexplored. Given the multitude of flavor …

Inhibition of chloride secretion in human bronchial epithelial cells by cigarette smoke extract

JL Kreindler, AD Jackson, PA Kemp… - … of physiology-lung …, 2005 - journals.physiology.org
Chronic bronchitis, a disease mainly of cigarette smokers, shares many clinical features with
cystic fibrosis, a disease of altered ion transport, suggesting that the negative effects of …

Chronic inhalation of e-cigarette vapor containing nicotine disrupts airway barrier function and induces systemic inflammation and multiorgan fibrosis in mice

LE Crotty Alexander, CA Drummond… - American Journal …, 2018 - journals.physiology.org
Electronic (e)-cigarettes theoretically may be safer than conventional tobacco. However, our
prior studies demonstrated direct adverse effects of e-cigarette vapor (EV) on airway cells …

Cigarette and ENDS preparations differentially regulate ion channels and mucociliary clearance in primary normal human bronchial 3D cultures

RE Rayner, P Makena, GL Prasad… - American Journal of …, 2019 - journals.physiology.org
Cigarette smoking is known to disrupt the normal mucociliary function of the lungs, whereas
the effect of electronic nicotine delivery systems (ENDS) is not completely understood. This …

Cigarette smoke-induced Ca2+ release leads to cystic fibrosis transmembrane conductance regulator (CFTR) dysfunction

JE Rasmussen, JT Sheridan, W Polk, CM Davies… - Journal of Biological …, 2014 - ASBMB
Chronic obstructive pulmonary disease affects 64 million people and is currently the fourth
leading cause of death worldwide. Chronic obstructive pulmonary disease includes both …

Flavored e-cigarette liquids reduce proliferation and viability in the CALU3 airway epithelial cell line

TR Rowell, SL Reeber, SL Lee… - … of Physiology-Lung …, 2017 - journals.physiology.org
E-cigarettes are generally thought of as a safer smoking alternative to traditional cigarettes.
However, little is known about the effects of e-cigarette liquids (e-liquids) on the lung. Since …

Cigarette smoke induces systemic defects in cystic fibrosis transmembrane conductance regulator function

SV Raju, PL Jackson, CA Courville… - American journal of …, 2013 - atsjournals.org
Rationale: Several extrapulmonary disorders have been linked to cigarette smoking.
Smoking is reported to cause cystic fibrosis transmembrane conductance regulator (CFTR) …

[HTML][HTML] Cigarette smoke exposure induces CFTR internalization and insolubility, leading to airway surface liquid dehydration

LA Clunes, CM Davies, RD Coakley… - The FASEB …, 2012 - ncbi.nlm.nih.gov
Cigarette smoke (CS) exposure induces mucus obstruction and the development of chronic
bronchitis (CB). While many of these responses are determined genetically, little is known …

Sub-ohm vaping increases the levels of carbonyls, is cytotoxic, and alters gene expression in human bronchial epithelial cells exposed at the air–liquid interface

A Noël, E Hossain, Z Perveen, H Zaman, AL Penn - Respiratory research, 2020 - Springer
Background Exposure to electronic-cigarette (e-cig) aerosols induces potentially fatal e-cig
or vaping-associated lung injury (EVALI). The cellular and molecular mechanisms …