Staphylococcus aureus is a common cause of surgical-site infections, including those
arising after craniotomy, which is performed to access the brain for the treatment of tumors …

Craniotomies are performed to treat a variety of intracranial pathology. Surgical site infection
remains a complication of craniotomy despite the use of prophylactic antibiotics and …

Neurosurgery for brain tumor resection or epilepsy treatment requires a craniotomy to gain
access to the brain. Despite prophylactic measures, infectious complications occur at a …

Background Treatment of brain tumors, epilepsy, or hemodynamic abnormalities requires a
craniotomy to access the brain. Nearly 1 million craniotomies are performed in the US …

Bacterial infections in the central nervous system (CNS) can be life threatening and often
impair neurological function. Biofilm infection is a complication following craniotomy, a …

Background A craniotomy is required to access the brain for tumor resection or epilepsy
treatment, and despite precautionary measures, infectious complications occur at a …

Severe sepsis and septic shock are lethal complications of infection, characterised by
dysregulated inflammatory and immune responses. Our understanding of the pathogenesis …

Decompressive craniectomy is often required after head trauma, stroke, or cranial bleeding
to control subsequent brain swelling and prevent death. The infection rate after cranial bone …

Background Epigenetic programming, dynamically regulated by histone acetylation, may
play a key role in the pathophysiology of sepsis. We examined whether histone deacetylase …

Histone deacetylases (HDACs) control gene expression by deacetylating histones and
nonhistone proteins. HDAC inhibitors (HDACi) are powerful anticancer drugs that exert anti …