[HTML][HTML] Plasticity and crosstalk of mesenchymal stem cells and macrophages in immunomodulation in sepsis

X Tao, J Wang, B Liu, P Cheng, D Mu, H Du… - Frontiers in …, 2024 - frontiersin.org
Sepsis is a multisystem disease characterized by dysregulation of the host immune
response to infection. Immune response kinetics play a crucial role in the pathogenesis and …

Immunomodulatory cell therapy in sepsis: have we learnt lessons from the past?

G Monneret, F Venet - Expert Review of Anti-infective Therapy, 2010 - Taylor & Francis
Evaluation of: Mei SH, Haitsma JJ, Dos Santos CC et al. Mesenchymal stem cells reduce
inflammation while enhancing bacterial clearance and improving survival in sepsis. Am. J …

[HTML][HTML] Mesenchymal stem cells as a therapeutic tool to treat sepsis

E Lombardo, T van der Poll, O DelaRosa… - World journal of stem …, 2015 - ncbi.nlm.nih.gov
Sepsis is a clinical syndrome caused by a deregulated host response to an infection. Sepsis
is the most frequent cause of death in hospitalized patients. Although knowledge of the …

Role of the regulation of mesenchymal stem cells on macrophages in sepsis

J Xing, R Wang, F Cui, L Song… - International Journal of …, 2023 - journals.sagepub.com
Sepsis is a common clinical critical disease with high mortality. The excessive release of
cytokines from macrophages is the main cause of out-of-control immune response in sepsis …

Mesenchymal stem cells in sepsis and associated organ dysfunction: a promising future or blind alley?

J Horák, L Nalos, V Martínková, J Beneš… - Stem cells …, 2017 - Wiley Online Library
Sepsis, newly defined as a life‐threatening organ dysfunction caused by a dysregulated
host response to infection, is the most common cause of death in ICUs and one of the …

Immunomodulatory and therapeutic effects of mesenchymal stem cells on organ dysfunction in sepsis

A Khosrojerdi, S Soudi, AZ Hosseini, F Eshghi… - Shock, 2021 - journals.lww.com
Sepsis is a life-threatening disorder that is caused by a dysregulated inflammatory response
during an infection. The disease mostly affects pregnant women, newborns, and patients in …

[HTML][HTML] Regulation of inflammatory cytokine storms by mesenchymal stem cells

L Wang, Y Li, M Xu, Z Deng, Y Zhao, M Yang… - Frontiers in …, 2021 - frontiersin.org
Mesenchymal stem cells (MSCs) have been widely used in preclinical and clinical trials for
various diseases and have shown great potential in the treatment of sepsis and coronavirus …

[HTML][HTML] Pathophysiology of sepsis and genesis of septic shock: the critical role of mesenchymal stem cells (MSCs)

M Daniel, Y Bedoui, D Vagner, L Raffray… - International Journal of …, 2022 - mdpi.com
The treatment of sepsis and septic shock remains a major public health issue due to the
associated morbidity and mortality. Despite an improvement in the understanding of the …

[HTML][HTML] Mesenchymal stem cells decrease lung inflammation during sepsis, acting through inhibition of the MAPK pathway

L Pedrazza, M Cubillos-Rojas, FC de Mesquita… - Stem Cell Research & …, 2017 - Springer
Background Sepsis is a severe medical condition that ranks among the top 10 causes of
death worldwide and which has permanently high incidence rates. Mesenchymal stem cells …

The immunomodulatory and therapeutic effects of mesenchymal stromal cells for acute lung injury and sepsis

MSH Ho, SHJ Mei, DJ Stewart - Journal of cellular physiology, 2015 - Wiley Online Library
It is increasingly recognized that immunomodulation represents an important mechanism
underlying the benefits of many stem cell therapies, rather than the classical paradigm of …