A fast, sensitive, universal and accurate method for the determination of four different
tyrosine kinase inhibitors from biological material was developed using LC–MS/MS …

BACKGROUND: Increasing numbers of tyrosine kinase inhibitors (TKIs) were studied and
approved for therapy of malignancies and other diseases. The aim of this study was to …

Background: A liquid chromatography/tandem mass spectrometry assay was developed to
facilitate therapeutic drug monitoring (TDM) for 10 anticancer compounds (dasatinib …

A quantitative liquid chromatography (LC)-mass spectrometry (MS)/MS method in human
plasma was developed and validated for the tyrosine kinase inhibitors erlotinib, gefitinib …

The purpose of this study was to develop and validate a robust and sensitive LC–MS/MS
method for simultaneous determinations of various tyrosine kinase inhibitors (TKIs) in …

Several studies have shown that therapeutic drug monitoring of tyrosine kinase inhibitors
(TKI) can improve their benefit in cancer. An analytical tool has been developed in order to …

A rapid, sensitive and reproducible ultra-high performance liquid chromatography mass
spectrometry method was developed and validated for simultaneous determination of seven …

A sensitive, sophisticated and practical bioanalytical assay for the simultaneous
determination of six tyrosine kinase inhibitors (imatinib, sunitinib, nilotinib, dasatinib …

To support pharmacokinetic‐guided dosing in individual patients, a fast and accurate
method for simultaneous determination of anticancer tyrosine kinase inhibitors (TKIs) …

BACKGROUND: Tyrosine Kinase Inhibitors (TKIs) are a class of targeted drugs for the
treatment of malignant pathologies. The metabolic profile of these drugs can result in great …