Free radical formation and oxidative damage have been extensively investigated and
validated as important contributors to the pathophysiology of acute central nervous system …

Free radicals are highly reactive molecules generated predominantly during cellular
respiration and normal metabolism. Imbalance between cellular production of free radicals …

One of the most investigated molecular mechanisms involved in the secondary
pathophysiology of acute spinal cord injury (SCI) is free radical-induced, iron-catalyzed lipid …

Extensive evidence has demonstrated an important role of oxygen radical formation (ie,
oxidative stress) as a mediator of the secondary injury process that occurs following primary …

Oxidative stress plays a crucial role in traumatic brain injury (TBI) pathogenesis. Reactive
oxygen species (ROS) and reactive nitrogen species (RNS) formed in excess after TBI …

The role of reactive oxygen-induced oxidative damage to lipids (ie, lipid peroxidation, LP)
and proteins has been strongly supported in previous work. Most notably, a number of free …

The overproduction of reactive oxygen species (ROS) and reactive nitrogen species (RNS)
is a common underlying mechanism of many neuropathologies, as they have been shown to …

Although moderate concentrations of reactive oxygen species (ROS) and reactive nitrogen
species (RNS) are crucial for various physiological processes within the human body, their …

Reactive oxygen species-induced oxidative damage remains an extensively validated
secondary injury mechanism in traumatic brain injury (TBI) as demonstrated by the efficacy …

Due to a multiplicity of causes provoking traumatic brain injury (TBI), TBI is a highly
heterogeneous pathology, characterized by high mortality and disability rates. TBI is an …