Models of cardiac tissue electrophysiology are an important component of the Cardiac
Physiome Project, which is an international effort to build biophysically based multi-scale …

Computational modeling has contributed significantly to present understanding of cardiac
electrophysiology including cardiac conduction, excitation-contraction coupling, and the …

In this paper, we study a mathematical model of cardiac tissue based on explicit
representation of individual cells. In this EMI model, the extracellular (E) space, the cell …

Cardiac electrophysiology models are among the most mature and well‐studied
mathematical models of biological systems. This maturity is bringing new challenges as …

The conduction of electrical signals through cardiac tissue is essential for maintaining the
function of the heart, and conduction abnormalities are known to potentially lead to life …

We are currently witnessing the advent of a revolutionary new tool for biomedical research.
Complex biochemically, biophysically and pharmacologically detailed mathematical models …

Recent developments in cardiac simulation have rendered the heart the most highly
integrated example of a virtual organ. We are on the brink of a revolution in cardiac …

The simulation of cardiac electrical function is an example of a successful integrative
multiscale modelling approach that is directly relevant to human disease. Today we stand at …

Cardiac rhythms arise from electrical activity generated by precisely timed opening and
closing of ion channels in individual cardiac myocytes. These impulses spread throughout …

One of the most recent trends in cardiac electrophysiology is the development of integrative
anatomically accurate models of the heart, which include description of cardiac activity from …