Single-cell histone chaperones patterns guide intercellular communication of tumor microenvironment that contribute to breast cancer metastases
Abstract Background Histone chaperones (HCs) are crucial for governing genome stability
and gene expression in multiple cancers. However, the functioning of HCs in the tumor …
and gene expression in multiple cancers. However, the functioning of HCs in the tumor …
A three layered histone epigenetics in breast cancer metastasis
D Nandy, SM Rajam, D Dutta - Cell & Bioscience, 2020 - Springer
Thanks to the advancement in science and technology and a significant number of cancer
research programs being carried out throughout the world, the prevention, prognosis and …
research programs being carried out throughout the world, the prevention, prognosis and …
[HTML][HTML] HSET overexpression fuels tumor progression via centrosome clustering-independent mechanisms in breast cancer patients
Human breast tumors harbor supernumerary centrosomes in almost 80% of tumor cells.
Although amplified centrosomes compromise cell viability via multipolar spindles resulting in …
Although amplified centrosomes compromise cell viability via multipolar spindles resulting in …
Single-cell RNA sequencing reveals cell subpopulations in the tumor microenvironment contributing to hepatocellular carcinoma
J Gao, Z Li, Q Lu, J Zhong, L Pan, C Feng… - Frontiers in Cell and …, 2023 - frontiersin.org
Background: Hepatocellular carcinoma (HCC) is among the deadliest cancers worldwide,
and advanced HCC is difficult to treat. Identifying specific cell subpopulations in the tumor …
and advanced HCC is difficult to treat. Identifying specific cell subpopulations in the tumor …
[HTML][HTML] HES1 promotes breast cancer stem cells by elevating Slug in triple-negative breast cancer
X Li, Y Li, X Du, X Wang, S Guan, Y Cao… - International journal of …, 2021 - ncbi.nlm.nih.gov
Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer.
TNBC is enriched with breast cancer stem cells (BCSCs), which are responsible for cancer …
TNBC is enriched with breast cancer stem cells (BCSCs), which are responsible for cancer …
Lactate dehydrogenase-A (LDH-A) preserves cancer stemness and recruitment of tumor-associated macrophages to promote breast cancer progression
S Wang, L Ma, Z Wang, H He, H Chen, Z Duan… - Frontiers in …, 2021 - frontiersin.org
Increasing evidence reveals that breast cancer stem cells (BCSCs) subtypes with distinct
properties are regulated by their abnormal metabolic changes; however, the specific …
properties are regulated by their abnormal metabolic changes; however, the specific …
RNA-sequencing reveals heat shock 70-kDa protein 6 (HSPA6) as a novel thymoquinone-upregulated gene that inhibits growth, migration, and invasion of triple …
S Shen, C Wei, J Fu - Frontiers in Oncology, 2021 - frontiersin.org
Objective Breast cancer has become the first highest incidence which surpasses lung
cancer as the most commonly diagnosed cancer, and the second highest mortality among …
cancer as the most commonly diagnosed cancer, and the second highest mortality among …
Hsp27 participates in the maintenance of breast cancer stem cells through regulation of epithelial-mesenchymal transition and nuclear factor-κB
L Wei, TT Liu, HH Wang, HM Hong, AL Yu… - Breast cancer …, 2011 - Springer
Abstract Introduction Heat shock proteins (HSPs) are normally induced under environmental
stress to serve as chaperones for maintenance of correct protein folding but they are often …
stress to serve as chaperones for maintenance of correct protein folding but they are often …
Single-cell transcriptomics reveal the heterogeneity and dynamic of cancer stem-like cells during breast tumor progression
G Jiang, J Tu, L Zhou, M Dong, J Fan, Z Chang… - Cell Death & …, 2021 - nature.com
Breast cancer stem-like cells (BCSCs) play vital roles in tumorigenesis and progression.
However, the origin and dynamic changes of BCSCs are still to be elucidated. Using the …
However, the origin and dynamic changes of BCSCs are still to be elucidated. Using the …
[HTML][HTML] Hedgehog pathway orchestrates the interplay of histone modifications and tailors combination epigenetic therapies in breast cancer
Epigenetic therapies that cause genome-wide epigenetic alterations, could trigger local
interplay between different histone marks, leading to a switch of transcriptional outcome and …
interplay between different histone marks, leading to a switch of transcriptional outcome and …