Age-related cerebrovascular pathologies, ranging from cerebromicrovascular functional and
structural alterations to large vessel atherosclerosis, promote the genesis of vascular …

Age-related impairment of neurovascular coupling (NVC;“functional hyperemia”) is a critical
factor in the development of vascular cognitive impairment (VCI). Recent geroscience …

Structural and functional integrity of the cerebral vasculature ensures proper brain
development and function, as well as healthy aging. The inability of the brain to store energy …

Epidemiological studies show that obesity has deleterious effects on the brain and cognitive
function in the elderly population. However, the specific mechanisms through which aging …

As the population of the Western world is aging, there is increasing awareness of age-
related impairments in cognitive function and a rising interest in finding novel approaches to …

Understanding the bases of aging-related cognitive decline remains a central challenge in
neurobiology. Quantitative studies reveal little change in the number of neurons or synapses …

Proper functioning of the brain is dependent on integrity of the cerebral vasculature. During
ageing, a number of factors including aortic or arterial stiffness, autonomic dysregulation …

The adult mammalian brain contains distinct neurogenic niches harboring populations of
neural stem cells (NSCs) with the capacity to sustain the generation of specific subtypes of …

Aging is associated with a significant deficiency in circulating insulin-like growth factor-1
(IGF-1), which has an important role in the pathogenesis of age-related vascular cognitive …

Restorative strategies after stroke are focused on the remodeling of cerebral endothelial
cells and brain parenchymal cells. The latter, ie, neurons, neural precursor cells and glial …