Sensory experience and the resulting synaptic activity within the brain are critical for the
proper development of neural circuits. Experience-driven synaptic activity causes membrane …

Activity-dependent plasticity of vertebrate neurons allows the brain to respond to its
environment. During brain development, both spontaneous and sensory-driven neural …

Sensory experience is critical for the proper development and plasticity of the brain
throughout life. Successful adaptation to the environment is necessary for the survival of an …

Proper brain function requires stringent balance of excitatory and inhibitory synapse
formation during neural circuit assembly. Mutation of genes that normally sculpt and …

One of the unique characteristics of higher organisms is their ability to learn and adapt to
changes in their environment. This plasticity is largely a result of the brain's ability to convert …

Modifications of neuronal circuits allow the brain to adapt and change with experience. This
plasticity manifests during development and throughout life, and can be remarkably long …

Learning and memory are basic functions of the brain that allowed human evolution. It is
well accepted that during learning and memory formation the dynamic establishment of new …

Recent advances in genomics have revealed a wide spectrum of genetic variants
associated with neurodevelopmental disorders at an unprecedented scale. An increasing …

Synaptic activity regulates the expression of a set of neuronal gene products that are
important for neuronal survival and differentiation, synaptogenesis and, ultimately, complex …

Poised for relay or storage of synaptic information, the postsynaptic neuron must assimilate
a variety of incoming synaptic signals and then integrate these into short-and long-term …