Alzheimer's disease (AD) is one of the leading causes for disability and death affecting
millions of people worldwide. Thus, novel therapeutic strategies are needed to reduce brain …

Histamine H3 receptor antagonists enhance cognition in preclinical models and have been
proposed as novel therapeutics for cognitive disorders, in particular Alzheimer's disease …

H3 antagonists increase the release of brain histamine, acetylcholine, noradrenaline, and
dopamine, neurotransmitters that are known to modulate cognitive processes. The ability to …

Background and purpose: Histamine H3 receptor antagonists are currently being evaluated
for their potential use in a number of central nervous system disorders including Alzheimer's …

6-[(3-Cyclobutyl-2, 3, 4, 5-tetrahydro-1 H-3-benzazepin-7-yl) oxy]-N-methyl-3-
pyridinecarboxamide hydrochloride (GSK189254) is a novel histamine H3 receptor …

In studies on the treatment of Alzheimer's disease (AD), in which cognition is enhanced even
modestly or selectively, it has been considered that the histamine H3 receptor (H3R) may be …

Alzheimer's disease (AD) is an age-related neurodegenerative disease, which characterized
by deposition of amyloid-β (Aβ) plaques, neurofibrillary tangles, neuronal loss, and …

Background: No comprehensive meta-analysis has been performed concerning the efficacy
and tolerability of histamine H3 receptor antagonists (H3R-ANTs) in Alzheimer's disease …

Background: The histamine H3 receptor plays a critical role in the negative neuromodulation
of neurotransmitters involved in cognitive function. H3 receptor antagonists/inverse agonists …

The role of histamine H3 receptors (H3Rs) in memory and the prospective of H3R
antagonists in pharmacological control of neurodegenerative disorders, eg, Alzheimer's …