TRH is a tripeptide amide that functions as a neurotransmitter but also serves as a
neurohormone that has a critical role in the central regulation of the hypothalamic-pituitary …

This review presents the findings that led to the discovery of TRH and the understanding of
the central mechanisms that control hypothalamus–pituitary–thyroid axis (HPT) activity. The …

The hypothalamic-pituitary-thyroid (HPT) axis plays a critical role in mediating changes in
metabolism and thermogenesis. Thus, the central regulation of the thyroid axis by …

Thyroid hormone (TH) plays a critical role in mediating changes in development and
metabolism in humans. Thus, circulating TH levels are regulated by a number of distinct …

Hypophysiotropic thyrotropin-releasing hormone (TRH): synthesizing neurons reside in the
hypothalamic paraventricular nucleus (PVN) and are the central regulators of the …

The functions of thyrotropin-releasing hormone (TRH) in the central nervous system (CNS)
can be conceptualized as performed by four anatomically distinct components that together …

Regulation of the hypothalamic-pituitary-thyroid (HPT) axis is dependent upon the secretion
of thyrotropin-releasing hormone (TRH), a tripeptide originating in the hypothalamic …

Thyroid hormone (TH) signaling plays an important role in development and adult life. Many
organisms may have evolved under selective pressure of exogenous TH, suggesting that …

Thyrotropin-releasing hormone (TRH) has an important role in the regulation of energy
homeostasis not only through effects on thyroid function orchestrated through …

The hypothalamus‐pituitary‐thyroid (HPT) axis determines the set point of thyroid hormone
(TH) production. Hypothalamic thyrotropin‐releasing hormone (TRH) stimulates the …