BACKGROUND Germ cell depletion caused by chemical or physical toxicity, disease or
genetic predisposition can occur at any age. Although semen cryopreservation is the first …

Male infertility management has made significant progress during the past three decades,
especially after the introduction of intracytoplasmic sperm injection in 1992. However, many …

STUDY QUESTION What clinical practices, patient management strategies and
experimental methods are currently being used to preserve and restore the fertility of …

Young boys undergoing gonadotoxic treatments are at high risk of spermatogonial stem cell
(SSC) loss and fertility problems later in life. Stem cell loss can also occur in specific genetic …

BACKGROUND Fertility in adult life may be severely impaired by gonadotoxic therapies. For
young boys who do not yet produce spermatozoa, cryopreservation of immature testicular …

STUDY QUESTION Is there a better alternative to the conventional cryopreservation
protocols for human testicular tissue banking? SUMMARY ANSWER Uncontrolled slow …

BACKGROUND Successful cryopreservation of gonadal tissue is an important factor in
guaranteeing the fertility preservation via germ cell or testicular tissue transplantation. The …

Objective To investigate the efficacy of vitrification, rapid freezing, and slow freezing in
preserving testicular tissue for subsequent isolation of spermatogonial stem cells. Design …

BACKGROUND Infertility is an important side effect of treatments used for cancer and other
non-malignant conditions in males. This may be due to the loss of spermatogonial stem cells …

Spermatogonial stem cells open novel strategies for preservation of testicular tissue and
fertility preservation in boys and men exposed to gonadotoxic therapies. This review …