Lung Cancer-Targeted [131I]-Iodoshikonin as Theranostic Agent: Radiolabeling, In Vivo Pharmacokinetics and Biodistribution
AA Selim, MA Motaleb, HA Fayez - Pharmaceutical Chemistry Journal, 2022 - Springer
Shikonin has been reported to exhibit high affinity toward lung cells and recited to inhibit the
migration and invasion of lung cancer cells and suppress their growth. Shikonin cause …
migration and invasion of lung cancer cells and suppress their growth. Shikonin cause …
Extraction, purification and radioiodination of Khellin as cancer theranostic agent
Khellin was successfully extracted from Ammi visnaga fruits with a recovery percent of
96.15%. Next radio-iodination of Khellin was successfully achieved with a high yield. The …
96.15%. Next radio-iodination of Khellin was successfully achieved with a high yield. The …
Synthesis and Evaluation of 131I-Skyrin as a Necrosis Avid Agent for Potential Targeted Radionuclide Therapy of Solid Tumors
C Wang, Q Jin, S Yang, D Zhang, Q Wang… - Molecular …, 2016 - ACS Publications
An innovative anticancer approach targeted to necrotic tissues, which serves as a
noncancerous and generic anchor, may present a breakthrough. Necrosis avid agents with …
noncancerous and generic anchor, may present a breakthrough. Necrosis avid agents with …
Synthesis and preclinical pharmacological evaluation of a novel 99m Tc–shikonin as a potential tumor imaging agent
Shikonin was isolated from Ratanjot pigment then the obtained shikonin was well
characterized. This study is aimed to optimize radiolabeling yield of shikonin with 99m Tc …
characterized. This study is aimed to optimize radiolabeling yield of shikonin with 99m Tc …
Radiosensitizing Effect of Schinifoline from Zanthoxylum schinifolium Sieb et Zucc on Human Non-Small Cell Lung Cancer A549 Cells: A Preliminary in Vitro …
CF Wang, L Fan, M Tian, XS Qi, JX Liu, JB Feng, SS Du… - Molecules, 2014 - mdpi.com
Schinifoline (SF), a 4-quinolinone derivative, was found in Zanthoxylum schinifolium for the
first time. 4-Quinolinone moieties are thought to have cytotoxic activity and are often used as …
first time. 4-Quinolinone moieties are thought to have cytotoxic activity and are often used as …
Mechanisms behind the inhibition of lung adenocarcinoma cell by shikonin
W Lan, S Wan, W Gu, H Wang, S Zhou - Cell biochemistry and biophysics, 2014 - Springer
Shikonin, a natural naphthoquinone isolated from a traditional Chinese medicinal herb, can
exert inhibitory effect on tumor cell growth. However, little has been known concerning the …
exert inhibitory effect on tumor cell growth. However, little has been known concerning the …
Shikonin attenuates lung cancer cell adhesion to extracellular matrix and metastasis by inhibiting integrin β1 expression and the ERK1/2 signaling pathway
H Wang, C Wu, S Wan, H Zhang, S Zhou, G Liu - Toxicology, 2013 - Elsevier
Integrin β1 facilitates cancer cell adhesion, migration and metastasis by activating
intracellular signaling pathways including the ERK and PI3K signaling pathways. In previous …
intracellular signaling pathways including the ERK and PI3K signaling pathways. In previous …
Radioiodination, nasal nanoformulation and preliminary evaluation of isovanillin: a new potential brain cancer-targeting agent
OA El-Kawy, HA Shweeta, KM Attallah - Applied Radiation and Isotopes, 2022 - Elsevier
Brain cancer is a challenging disease to treat using conventional approaches. The present
investigation aimed to develop a radiopharmaceutical targeting brain cancer based on …
investigation aimed to develop a radiopharmaceutical targeting brain cancer based on …
[PDF][PDF] Antimetastatic activity of seongsanamide B in γ-irradiated human lung cancer
GH Ryoo, GJ Kim, AR Han, CH Jin, H Lee, JW Nam… - Heliyon, 2023 - cell.com
Lung cancer, which has a high incidence and mortality rates, often metastasizes and
exhibits resistance to radiation therapy. Seongsanamide B has conformational features that …
exhibits resistance to radiation therapy. Seongsanamide B has conformational features that …
Shikonin induces apoptosis, necrosis, and premature senescence of human A549 lung cancer cells through upregulation of p53 expression
YC Yeh, TJ Liu, HC Lai - Evidence‐based Complementary and …, 2015 - Wiley Online Library
Shikonin, a natural naphthoquinone pigment isolated from Lithospermum erythrorhizon, has
been reported to suppress growth of various cancer cells. This study was aimed to …
been reported to suppress growth of various cancer cells. This study was aimed to …