RNA modulation has become a promising therapeutic approach for the treatment of several
types of disease. The emerging field of noncoding RNA-based therapies has now come to …

Cardiovascular diseases are the leading cause of death globally and are associated with
increasing financial expenditure. With the availability of next-generation sequencing …

Novel bio-therapeutic agents that harness the properties of small, non-coding nucleic acids
hold great promise for clinical applications. These include antisense oligonucleotides that …

A growing body of evidence indicates that cardiac regeneration after myocardial infarction
can be achieved by stimulating the endogenous capacity of cardiomyocytes (CMs) to …

Noncoding RNAs have been shown to exert important physiological and pathophysiological
functions. Various studies suggest that modulating noncoding RNAs may provide a …

Since our knowledge on structure and function of messenger RNA (mRNA) has expanded
from merely being an intermediate molecule between DNA and proteins to the notion that …

Background: The discovery that much of the non–protein-coding genome is transcribed and
plays a diverse functional role in fundamental cellular processes has led to an explosion in …

MicroRNAs act as negative regulators of gene expression by inhibiting the translation or
promoting the degradation of target mRNAs. Because individual microRNAs often regulate …

Cardiovascular diseases are the most common causes of human morbidity and mortality
despite significant therapeutic improvements by surgical, interventional and …

Cardiovascular diseases are a major cause of human morbidity and mortality, posing a high
socioeconomic burden on the health sector worldwide. microRNAs (miRNAs) constitute a …