Alzheimer's disease (AD) is a complex neurological disorder of uncertain aetiology,
although substantial research has been conducted to explore important factors related to …

Inheritance appears to play a strong role in terms of human longevity and also in risk for
chronic neurodegenerative diseases of late life such as Alzheimer's disease (AD) …

Recent genome wide association studies have identified a number of single nucleotide
polymorphisms associated with late onset Alzheimer's disease (LOAD). We examined the …

Background Polygenic risk scores for Alzheimer's disease (AD-PRSs) have been associated
with cognition. However, few studies have examined the effect of AD-PRS beyond the APOE …

Most people's cognitive abilities decline with age, with significant and partly genetically
driven, individual differences in rate of change. Although APOE ɛ4 and genetic scores for …

Introduction. A family history of Alzheimer's disease is a significant risk factor for its onset, but
the genetic risk associated with possessing multiple risk alleles is still poorly understood …

Genome-wide association studies (GWAS) conducted in European ancestry (EA) have
identified hundreds of single-nucleotide polymorphisms (SNPs) associated with general …

Factors contributing to increased risk for Alzheimer's disease (AD) include age, sex, genes,
and family history of AD. Several risk factors for AD are endogenous; however, accumulating …

Alzheimer's disease (AD) and non-pathological cognitive aging have phenotypic similarities
which may be influenced by an overlapping set of genetic variants. Genome-wide complex …

Targeting modifiable risk factors may help to prevent Alzheimer's disease (AD), but the
pathways by which these risk factors influence AD risk remain incompletely understood. We …