From virus evolution to vector revolution: use of naturally occurring serotypes of adeno-associated virus (AAV) as novel vectors for human gene therapy
Gene transfer vectors based on the human adeno-associated virus serotype 2 (AAV-2) have
been developed and tested in pre-clinical studies for almost 20 years, and are currently …
been developed and tested in pre-clinical studies for almost 20 years, and are currently …
[HTML][HTML] The AAV vector toolkit: poised at the clinical crossroads
The discovery of naturally occurring adeno-associated virus (AAV) isolates in different
animal species and the generation of engineered AAV strains using molecular genetics …
animal species and the generation of engineered AAV strains using molecular genetics …
[HTML][HTML] Adeno-associated virus serotypes: vector toolkit for human gene therapy
Z Wu, A Asokan, RJ Samulski - Molecular therapy, 2006 - cell.com
Recombinant adeno-associated viral (AAV) vectors have rapidly advanced to the forefront of
gene therapy in the past decade. The exponential progress of AAV-based vectors has been …
gene therapy in the past decade. The exponential progress of AAV-based vectors has been …
Adeno-associated virus vectors in clinical trials
BJ Carter - Human gene therapy, 2005 - liebertpub.com
ADENO-ASSOCIATED VIRUS (AAV) VECTORS were first devel-oped 20 years ago (Carter,
2004) and an AAV vector was first administered to a human subject in November 1995 …
2004) and an AAV vector was first administered to a human subject in November 1995 …
Gene therapy progress and prospects: recombinant adeno-associated virus (rAAV) vectors
TR Flotte - Gene therapy, 2004 - nature.com
Recombinant adeno-associated virus (rAAV) vectors are unique among the vector classes
currently available for human gene therapy in that they are based upon a class of viruses …
currently available for human gene therapy in that they are based upon a class of viruses …
[HTML][HTML] Rationale and strategies for the development of safe and effective optimized AAV vectors for human gene therapy
A Srivastava - Molecular Therapy-Nucleic Acids, 2023 - cell.com
Recombinant adeno-associated virus (AAV) vectors have been, or are currently in use, in
332 phase I/II/III clinical trials in a number of human diseases, and in some cases …
332 phase I/II/III clinical trials in a number of human diseases, and in some cases …
Infectious clones and vectors derived from adeno-associated virus (AAV) serotypes other than AAV type 2
EA Rutledge, CL Halbert, DW Russell - Journal of virology, 1998 - Am Soc Microbiol
Adeno-associated viruses (AAVs) are single-stranded dependent parvoviruses being
developed as transducing vectors. Although at least five serotypes exist (AAV types 1 to 5 …
developed as transducing vectors. Although at least five serotypes exist (AAV types 1 to 5 …
[HTML][HTML] The state of the art of adeno-associated virus-based vectors in gene therapy
RS Coura, NB Nardi - Virology journal, 2007 - Springer
The adeno-associated virus (AAV) has rapidly gained popularity in gene therapy since the
establishment of the first AAV2 infectious clone, in 1982, due to some of their distinguishing …
establishment of the first AAV2 infectious clone, in 1982, due to some of their distinguishing …
Production methods for gene transfer vectors based on adeno-associated virus serotypes
D Grimm - Methods, 2002 - Elsevier
Vectors derived from adeno-associated virus serotype 2 (AAV-2) represent a most promising
tool for human gene transfer because these vectors are neither pathogenic nor toxic to the …
tool for human gene transfer because these vectors are neither pathogenic nor toxic to the …
Small but increasingly mighty: latest advances in AAV vector research, design, and evolution
Recombinant gene delivery vectors derived from naturally occurring or genetically
engineered adeno-associated viruses (AAV) have taken center stage in human gene …
engineered adeno-associated viruses (AAV) have taken center stage in human gene …