Host responses to tumor cells include tumor suppressing or promoting mechanisms. We
sought to detail the effect of Hedgehog (Hh) pathway inhibition on the composition of the …

Hedgehog–GLI (HH) signaling plays an essential role in embryogenesis and tissue
homeostasis. Aberrant activation of the pathway through mutations or other mechanisms is …

Elevated infiltration of immunosuppressive alternatively polarized (M2) macrophages is
associated with poor prognosis in patients with cancer. The tumor microenvironment …

Breast cancer (BC) is the leading cause of cancer-related mortality in women, only followed
by lung cancer. Given the importance of BC in public health, it is essential to identify …

Abstract The Hedgehog (Hh) signaling pathway plays a key role in a variety of processes,
such as embryogenesis and maintenance of adult tissue homeostasis. It is also becoming …

Hedgehog (Hh) signaling plays an important role in several malignancies but its clinical
significance in breast cancer is unclear. In a cohort of 279 patients with invasive ductal …

Targeting the hedgehog (HH) pathway to treat aggressive cancers of the brain, breast,
pancreas, and prostate has been ongoing for decades. Gli gene amplifications have been …

Uncontrolled activation of the Hedgehog/Glioma-associated oncogene (HH/GLI) pathway is
a potent oncogenic driver signal promoting numerous cancer hallmarks such as …

In addition to its role in embryonic development, the Hedgehog pathway has been shown to
be an active participant in cancer development, progression, and metastasis. Although this …

The Hedgehog (Hh) signaling pathway is pervasively involved in human malignancies,
making it an effective target for cancer treatment for decades. In addition to its direct role in …