Nickel compounds are known human carcinogens, but the exact molecular mechanisms of
nickel carcinogenesis are not known. Due to their abundance, histones are likely targets for …

Ni (II) compounds are well known as human carcinogens, though the molecular events
which are responsible for this are not yet fully understood. It has been proposed that the …

Nickel (II) compounds are established human carcinogens, but the molecular mechanisms
underlying their activity are only partially known. One mechanism may include mediation by …

Studies of 2 '-deoxyguanosine oxidation by hydrogen peroxide in the presence of CH3CO-
Cys-Ala-Ile-His-NH2 (CAIH) and/or NiCl2 have been carried out in 100 mM phosphate buffer …

Molecular mechanisms of nickel-induced carcinogenesis include interactions of Ni (II)
cations with histones. Previously, we demonstrated in vitro and in cells that Ni (II) cleaved off …

A combined pH-metric and spectroscopic (UV/vis, CD, NMR) study of the Ni (II) binding to
CH3CO-Thr-Glu-Ser-His-His-Lys-NH2 (AcTESHHKam), a blocked hexapeptide modeling a …

We have demonstrated previously that Ni (II) binds to the C-terminal− TESHHKAKGK motif of
isolated bovine histone H2A. At physiological pH, the bound Ni (II) assists in hydrolysis of …

Over the last years, we have been testing a hypothesis that molecular mechanisms of nickel-
induced carcinogenesis include interactions of this metal with major chromatin components; …

Nickel compounds are included among human carcinogens, though the molecular events
related to them are not yet completely known. It has been proposed that the basic element …

The molecular mechanisms of nickel-induced malignant cell transformation include effects
altering the structure and covalent modifications of core histones. Previously, we found that …