The heterochronic gene lin-28 is a regulator of developmental timing in the nematode
Caenorhabditis elegans. It must be expressed in the first larval stage and downregulated by …

Mutations in the heterochronic gene lin-28 of C. elegans cause precocious development
where diverse events specific to the second larval stage are skipped. lin-28 encodes a …

The gene lin-28 was originally identified through a mutant of the nematode Caenorhabditis
elegans displaying defects in developmental timing. It is expressed stage-specifically in …

Lin28 is a conserved cytoplasmic protein with an unusual pairing of RNA-binding motifs: a
cold shock domain and a pair of retroviral-type CCHC zinc fingers. In the nematode C …

lin-28 is a conserved regulator of cell fate succession in animals. In Caenorhabditis elegans,
it is a component of the heterochronic gene pathway that governs larval developmental …

The heterochronic gene lin-28 of the nematode Caenorhabditis elegans controls the relative
timing of diverse developmental events during the animal's larval stages. lin-28 is stage …

Summary h-4 is essential for the normal temporal control of diverse postembryonic
developmental events in C. elegans./in-4 acts by negatively regulating the level of LIN-14 …

During C. elegans development, the temporal pattern of many cell lineages is specified by
graded activity of the heterochronic gene Lin-14. Here we demonstrate that a temporal …

LIN28 is an RNA-binding protein that is expressed in many developing tissues. It can block
let-7 (Mirlet7) microRNA processing and help promote pluripotency. We have observed …

In C. elegans, heterochronic genes control the timing of cell fate determination during
development. Two heterochronic genes, let‐7 and lin‐4, encode microRNAs (miRNAs) that …