Abstract Neurofibromatosis type 1 (NF1) is associated with GABAergic dysfunction which
has been suggested as the underlying cause of cognitive impairments. Previous intervention …

Abstract Background Neurofibromatosis type 1 (NF1) is one of the most common genetic
disorders causing learning disabilities by mutations in the neurofibromin gene, an important …

Objective Lovastatin has been shown to reverse learning deficits in a mouse model of
Neurofibromatosis Type 1 (NF 1), a common monogenic disorder caused by a mutation in …

Background Neurofibromatosis type 1 is a common genetic disorder characterised by
neurocutaneous manifestations and cognitive and behavioural problems. Statins were …

In the Neurofibromatosis type 1 (NF1) mouse model, lovastatin, used clinically for
hypercholesterolemia, improves cognitive dysfunction. While such impairment has been …

Context Neurofibromatosis type 1 (NF1) is among the most common genetic disorders that
cause learning disabilities. Recently, it was shown that statin-mediated inhibition of 3 …

Objective: To assess the efficacy of lovastatin on visuospatial learning and attention for
treating cognitive and behavioral deficits in children with neurofibromatosis type 1 (NF1) …

Objective Rapid developments in understanding the molecular mechanisms underlying
cognitive deficits in neurodevelopmental disorders have increased expectations for targeted …

Background Cognitive impairment is a common medical issue in rat sarcoma (RAS) pathway
disorders, so-called RASopathies, like Neurofibromatosis type 1 (NF1) or Noonan syndrome …

Abstract Neurofibromatosis type 1 (NF1) is a neurodevelopmental disorder characterized by
a broad spectrum of cognitive deficits. In particular, executive dysfunction is recognized as a …