A sensitive, accurate and precise method was developed for the quantification of a large
number of organic acids in human urine by GC-MS/MS. The analytes were selected based …

In the current paper the analytical conditions for the determination of ten free organic acids
by GC-MS are studied with the aim to establish a method for organic acid profiling in human …

Gas chromatography/mass spectrometry (GC/MS) is the most suitable technique for the
diagnosis of disorders of organic acid metabolism, known as organic acidurias. They are …

Altogether 143 of the organic acids regularly occurring in urine of healthy individuals are
identified as methyl esters by gas chromatography-mass spectrometry with respect to their …

Organic acids occurring in physiological fluids comprise key metabolites of virtually all
pathways of intermediary metabolism and may also be derived from exogenous sources …

Sediment in urine may contain low-molecular-weight compounds that should be included in
the analysis. To date, no systematic investigation has addressed this issue. We investigated …

Seventy-six organic acids in urine specimens are determined with quantitative two
dimensional Gas Chromatography-Time of Flight Mass Spectrometry (GCxGC-TOFMS). The …

Abstract A novel 1, 1, 1, 2, 2, 3, 3-heptafluorobutyl chloroformate reagent (HFBCF) was
examined for in-situ derivatization of amino-carboxylic metabolites in human urine. The …

BACKGROUND: Gas chromatograph mass-spectrometric (GC/MS) method of analysis for
urinary organic acids is used for the diagnosis of a variety of metabolic disorders. The …

Abstract Metabolomics, a 'budding'discipline, may accurately reflect a specific phenotype
which is sensitive to genetic and epigenetic interactions. This rapidly evolving field in …