Targeted therapy for head and neck cancer: signaling pathways and clinical studies

Q Li, Y Tie, A Alu, X Ma, H Shi - Signal Transduction and Targeted …, 2023 - nature.com
Head and neck cancer (HNC) is malignant, genetically complex and difficult to treat and is
the sixth most frequent cancer, with tobacco, alcohol and human papillomavirus being major …

Targeted therapy in head and neck cancer

SK Kundu, M Nestor - Tumor Biology, 2012 - Springer
Head and neck squamous cell carcinoma (HNSCC) of multi-factorial etiopathogenesis is
rising worldwide. Treatment-associated toxicity problems and treatment failure in advanced …

Overview of current and future biologically based targeted therapies in head and neck squamous cell carcinoma

A Matta, R Ralhan - Head & neck oncology, 2009 - Springer
Recent advances in genomics, proteomics, bioinformatics and systems biology have
unraveled the complex aberrant signaling networks in cancer. The knowledge accrued has …

Current trends and future prospects of molecular targeted therapy in head and neck squamous cell carcinoma

N Kitamura, S Sento, Y Yoshizawa, E Sasabe… - International journal of …, 2020 - mdpi.com
In recent years, advances in drug therapy for head and neck squamous cell carcinoma
(HNSCC) have progressed rapidly. In addition to cytotoxic anti-cancer agents such as …

Clinical update on cancer: molecular oncology of head and neck cancer

Y Suh, I Amelio, T Guerrero Urbano, M Tavassoli - Cell death & disease, 2014 - nature.com
Head and neck cancers encompass a heterogeneous group of tumours that, in general, are
biologically aggressive in nature. These cancers remain difficult to treat and treatment can …

Head and neck cancer: from anatomy to biology

P Bose, NT Brockton, JC Dort - International journal of cancer, 2013 - Wiley Online Library
The 20th century saw great advances in anatomy‐based (surgery and radiotherapy) and
chemotherapy approaches for treating head and neck squamous cell carcinoma (HNSCC) …

Emerging drugs to treat squamous cell carcinomas of the head and neck

C Fung, JR Grandis - Expert opinion on emerging drugs, 2010 - Taylor & Francis
Importance of the field: Head and neck squamous cell carcinoma (HNSCC) is the eighth
leading cause of cancer death worldwide. Despite advances in surgery and chemoradiation …

Current and emerging molecular therapies for head and neck squamous cell carcinoma

F Kordbacheh, CS Farah - Cancers, 2021 - mdpi.com
Simple Summary Next-generation sequencing of head and neck squamous cell carcinoma
has revealed multiple new gene mutations, while simultaneously confirming the role of …

Promising new molecular targeted therapies in head and neck cancer

K Dorsey, M Agulnik - Drugs, 2013 - Springer
Despite advances in multimodality therapies for the treatment of squamous cell carcinoma of
the head and neck (SCCHN), survival rates, functional outcomes and toxicities of therapy …

Targeted therapies for squamous cell carcinoma of the head and neck: current knowledge and future directions

S Schmitz, KK Ang, J Vermorken, R Haddad… - Cancer treatment …, 2014 - Elsevier
Despite progress in the therapeutic management of patients with squamous cell carcinoma
of the head and neck (SCCHN), the mortality rate of patients presenting with advanced …