Are we dependent upon coffee and caffeine? A review on human and animal data
A Nehlig - Neuroscience & Biobehavioral Reviews, 1999 - Elsevier
Caffeine is the most widely used psychoactive substance and has been considered
occasionally as a drug of abuse. The present paper reviews available data on caffeine …
occasionally as a drug of abuse. The present paper reviews available data on caffeine …
Caffeine physical dependence: a review of human and laboratory animal studies
RR Griffiths, PP Woodson - Psychopharmacology, 1988 - Springer
Although caffeine is the most widely used behaviorally active drug in the world, caffeine
physical dependence has been poorly characterized in laboratory animals and only …
physical dependence has been poorly characterized in laboratory animals and only …
Human coffee drinking: reinforcing and physical dependence producing effects of caffeine.
RR Griffiths, GE Bigelow, IA Liebson - Journal of Pharmacology and …, 1986 - ASPET
In a residential research ward coffee drinking was studied in nine volunteer human subjects
with histories of heavy coffee drinking. The presence or absence of caffeine in the coffee …
with histories of heavy coffee drinking. The presence or absence of caffeine in the coffee …
Actions of caffeine in the brain with special reference to factors that contribute to its widespread use
BB Fredholm, K Bättig, J Holmén, A Nehlig… - Pharmacological …, 1999 - ASPET
Caffeine is the most widely consumed behaviorally active substance in the world. Almost all
caffeine comes from dietary sources (beverages and food), most of it from coffee and tea …
caffeine comes from dietary sources (beverages and food), most of it from coffee and tea …
The role of dopamine in the behavioral effects of caffeine in animals and humans
BE Garrett, RR Griffiths - Pharmacology Biochemistry and Behavior, 1997 - Elsevier
Dopamine has been proposed to mediate some of the behavioral effects of caffeine. This
review discusses cellular mechanisms of action that could explain the role of dopamine in …
review discusses cellular mechanisms of action that could explain the role of dopamine in …
Dose–response study of caffeine effects on cerebral functional activity with a specific focus on dependence
A Nehlig, S Boyet - Brain research, 2000 - Elsevier
Caffeine is a behavioral stimulant consumed on a worldwide basis. The question of whether
caffeine is addictive has been debated for over a decade. Caffeine acts as a mild positive …
caffeine is addictive has been debated for over a decade. Caffeine acts as a mild positive …
Caffeine: behavioral effects of withdrawal and related issues
PB Dews, CP O'Brien, J Bergman - Food and Chemical Toxicology, 2002 - Elsevier
Acquired tolerance to some behavioral effects of caffeine in humans is widely assumed to
occur but is poorly documented and appears, at most, to be of low magnitude. Withdrawal …
occur but is poorly documented and appears, at most, to be of low magnitude. Withdrawal …
Caffeine withdrawal symptoms following brief caffeine deprivation
BG Phillips-Bute, JD Lane - Physiology & behavior, 1997 - Elsevier
Phillips-Bute, BG and JD Lane. Caffeine withdrawal symptoms following brief caffeine
deprivation. PHYSIOL BEHAV 63 (1) 35–39, 1998.—The effects of short-term caffeine …
deprivation. PHYSIOL BEHAV 63 (1) 35–39, 1998.—The effects of short-term caffeine …
Caffeine withdrawal: a parametric analysis of caffeine dosing conditions
SM Evans, RR Griffiths - Journal of Pharmacology and Experimental …, 1999 - ASPET
Although caffeine is the most widely used behaviorally active drug in the world, caffeine
physical dependence has been only moderately well characterized in humans. Four double …
physical dependence has been only moderately well characterized in humans. Four double …
Caffeine use disorder: a comprehensive review and research agenda
SE Meredith, LM Juliano, JR Hughes… - Journal of caffeine …, 2013 - liebertpub.com
Caffeine is the most commonly used drug in the world. Although consumption of low to
moderate doses of caffeine is generally safe, an increasing number of clinical studies are …
moderate doses of caffeine is generally safe, an increasing number of clinical studies are …