Caffeine is the most widely used psychoactive substance and has been considered
occasionally as a drug of abuse. The present paper reviews available data on caffeine …

Although caffeine is the most widely used behaviorally active drug in the world, caffeine
physical dependence has been poorly characterized in laboratory animals and only …

In a residential research ward coffee drinking was studied in nine volunteer human subjects
with histories of heavy coffee drinking. The presence or absence of caffeine in the coffee …

Caffeine is the most widely consumed behaviorally active substance in the world. Almost all
caffeine comes from dietary sources (beverages and food), most of it from coffee and tea …

Dopamine has been proposed to mediate some of the behavioral effects of caffeine. This
review discusses cellular mechanisms of action that could explain the role of dopamine in …

Caffeine is a behavioral stimulant consumed on a worldwide basis. The question of whether
caffeine is addictive has been debated for over a decade. Caffeine acts as a mild positive …

Acquired tolerance to some behavioral effects of caffeine in humans is widely assumed to
occur but is poorly documented and appears, at most, to be of low magnitude. Withdrawal …

Phillips-Bute, BG and JD Lane. Caffeine withdrawal symptoms following brief caffeine
deprivation. PHYSIOL BEHAV 63 (1) 35–39, 1998.—The effects of short-term caffeine …

Although caffeine is the most widely used behaviorally active drug in the world, caffeine
physical dependence has been only moderately well characterized in humans. Four double …

Caffeine is the most commonly used drug in the world. Although consumption of low to
moderate doses of caffeine is generally safe, an increasing number of clinical studies are …