Potentially pathogenic airway bacteria and neutrophilic inflammation in treatment resistant severe asthma
Background Molecular microbiological analysis of airway samples in asthma has
demonstrated an altered microbiome in comparison to healthy controls. Such changes may …
demonstrated an altered microbiome in comparison to healthy controls. Such changes may …
[HTML][HTML] Inflammatory phenotypes in patients with severe asthma are associated with distinct airway microbiology
Background Asthma pathophysiology and treatment responsiveness are predicted by
inflammatory phenotype. However, the relationship between airway microbiology and …
inflammatory phenotype. However, the relationship between airway microbiology and …
[HTML][HTML] The airway microbiome in patients with severe asthma: associations with disease features and severity
Background Asthma is heterogeneous, and airway dysbiosis is associated with clinical
features in patients with mild-to-moderate asthma. Whether similar relationships exist among …
features in patients with mild-to-moderate asthma. Whether similar relationships exist among …
Sputum microbiome profiles identify severe asthma phenotypes of relative stability at 12 to 18 months
MI Abdel-Aziz, P Brinkman, SJH Vijverberg… - Journal of Allergy and …, 2021 - Elsevier
Background Asthma is a heterogeneous disease characterized by distinct phenotypes with
associated microbial dysbiosis. Objectives Our aim was to identify severe asthma …
associated microbial dysbiosis. Objectives Our aim was to identify severe asthma …
Eosinophilic airway inflammation in asthmatic patients is associated with an altered airway microbiome
A Sverrild, P Kiilerich, A Brejnrod, R Pedersen… - Journal of Allergy and …, 2017 - Elsevier
Background Asthmatic patients have higher microbiome diversity and an altered
composition, with more Proteobacteria and less Bacteroidetes compared with healthy …
composition, with more Proteobacteria and less Bacteroidetes compared with healthy …
Corticosteroid therapy and airflow obstruction influence the bronchial microbiome, which is distinct from that of bronchoalveolar lavage in asthmatic airways
DR Denner, N Sangwan, JB Becker, DK Hogarth… - Journal of Allergy and …, 2016 - Elsevier
Background The lung has a diverse microbiome that is modest in biomass. This microbiome
differs in asthmatic patients compared with control subjects, but the effects of clinical …
differs in asthmatic patients compared with control subjects, but the effects of clinical …
[HTML][HTML] Sputum microbiota in severe asthma patients: relationship to eosinophilic inflammation
Background Altered composition of airway microbiota has been reported in subjects
suffering from asthma but its relation to eosinophilic phenotype is unclear. Objective To …
suffering from asthma but its relation to eosinophilic phenotype is unclear. Objective To …
Features of the bronchial bacterial microbiome associated with atopy, asthma, and responsiveness to inhaled corticosteroid treatment
Background Compositional differences in the bronchial bacterial microbiota have been
associated with asthma, but it remains unclear whether the findings are attributable to …
associated with asthma, but it remains unclear whether the findings are attributable to …
Type 2–high asthma is associated with a specific indoor mycobiome and microbiome
LE Vandenborght, R Enaud, C Urien, N Coron… - Journal of Allergy and …, 2021 - Elsevier
Background The links between microbial environmental exposures and asthma are well
documented, but no study has combined deep sequencing results from pulmonary and …
documented, but no study has combined deep sequencing results from pulmonary and …
Airway microbiota in severe asthma and relationship to asthma severity and phenotypes
Background The lower airways harbor a community of bacterial species which is altered in
asthma. Objectives We examined whether the lower airway microbiota were related to …
asthma. Objectives We examined whether the lower airway microbiota were related to …
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