Potentially pathogenic airway bacteria and neutrophilic inflammation in treatment resistant severe asthma

BJ Green, S Wiriyachaiporn, C Grainge, GB Rogers… - PloS one, 2014 - journals.plos.org
Background Molecular microbiological analysis of airway samples in asthma has
demonstrated an altered microbiome in comparison to healthy controls. Such changes may …

[HTML][HTML] Inflammatory phenotypes in patients with severe asthma are associated with distinct airway microbiology

SL Taylor, LEX Leong, JM Choo, S Wesselingh… - Journal of Allergy and …, 2018 - Elsevier
Background Asthma pathophysiology and treatment responsiveness are predicted by
inflammatory phenotype. However, the relationship between airway microbiology and …

[HTML][HTML] The airway microbiome in patients with severe asthma: associations with disease features and severity

YJ Huang, S Nariya, JM Harris, SV Lynch… - Journal of Allergy and …, 2015 - Elsevier
Background Asthma is heterogeneous, and airway dysbiosis is associated with clinical
features in patients with mild-to-moderate asthma. Whether similar relationships exist among …

Sputum microbiome profiles identify severe asthma phenotypes of relative stability at 12 to 18 months

MI Abdel-Aziz, P Brinkman, SJH Vijverberg… - Journal of Allergy and …, 2021 - Elsevier
Background Asthma is a heterogeneous disease characterized by distinct phenotypes with
associated microbial dysbiosis. Objectives Our aim was to identify severe asthma …

Eosinophilic airway inflammation in asthmatic patients is associated with an altered airway microbiome

A Sverrild, P Kiilerich, A Brejnrod, R Pedersen… - Journal of Allergy and …, 2017 - Elsevier
Background Asthmatic patients have higher microbiome diversity and an altered
composition, with more Proteobacteria and less Bacteroidetes compared with healthy …

Corticosteroid therapy and airflow obstruction influence the bronchial microbiome, which is distinct from that of bronchoalveolar lavage in asthmatic airways

DR Denner, N Sangwan, JB Becker, DK Hogarth… - Journal of Allergy and …, 2016 - Elsevier
Background The lung has a diverse microbiome that is modest in biomass. This microbiome
differs in asthmatic patients compared with control subjects, but the effects of clinical …

[HTML][HTML] Sputum microbiota in severe asthma patients: relationship to eosinophilic inflammation

N Li, R Qiu, Z Yang, J Li, KF Chung, N Zhong… - Respiratory …, 2017 - Elsevier
Background Altered composition of airway microbiota has been reported in subjects
suffering from asthma but its relation to eosinophilic phenotype is unclear. Objective To …

Features of the bronchial bacterial microbiome associated with atopy, asthma, and responsiveness to inhaled corticosteroid treatment

J Durack, SV Lynch, S Nariya, NR Bhakta… - Journal of allergy and …, 2017 - Elsevier
Background Compositional differences in the bronchial bacterial microbiota have been
associated with asthma, but it remains unclear whether the findings are attributable to …

Type 2–high asthma is associated with a specific indoor mycobiome and microbiome

LE Vandenborght, R Enaud, C Urien, N Coron… - Journal of Allergy and …, 2021 - Elsevier
Background The links between microbial environmental exposures and asthma are well
documented, but no study has combined deep sequencing results from pulmonary and …

Airway microbiota in severe asthma and relationship to asthma severity and phenotypes

Q Zhang, M Cox, Z Liang, F Brinkmann, PA Cardenas… - PloS one, 2016 - journals.plos.org
Background The lower airways harbor a community of bacterial species which is altered in
asthma. Objectives We examined whether the lower airway microbiota were related to …