Beta amyloid peptide Aβ 1–42 (Aβ42) has a unique dual role in the human organism, as
both the peptide with an important physiological function and one of the most toxic biological …

Amyloid proteins are known to be the main cause of numerous degenerative and
neurodegenerative diseases. In general, amyloids are misfolded from monomers and they …

Recent experimental data revealed that small, soluble Amyloid beta (Aβ42) oligomers,
especially dimers impair synaptic plasticity and memory leading to Alzheimer's disease …

In this simulation study, we present a comparison of the secondary structure of the two major
alloforms of the Alzheimer's peptide (Aβ1–40 and Aβ1–42) on the basis of molecular …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive
accumulation of amyloid-beta (Aβ) peptides in brain. In the present study, two familial Aβ42 …

The properties of the amyloid‐β peptide that lead to aggregation associated with Alzheimer's
disease are not fully understood. This study aims at identifying conformational differences …

Oligomeric assemblies of the amyloid β-protein (Aβ) have been implicated in the
pathogenesis of Alzheimer's disease as a primary source of neurotoxicity. Recent in vitro …

Abstract The amyloid Aβ (1–40) peptide of Alzheimer's disease was chosen as model
compound. This Aβ peptide is an intrinsically soluble peptide; the C-terminal amino acids …

The 40–42 residue amyloid β-protein (Aβ) plays a central role in the pathogenesis of
Alzheimer's disease (AD). Of the two main alloforms, Aβ40 and Aβ42, the longer Aβ42 is …

Alzheimer's disease (AD) is a neurodegenerative disorder that occurs due to progressive
deposition of amyloid β-protein (Aβ) in the brain. Stable conformations of solvated Aβ 1-42 …