In postmenopausal women, almost 100% of active sex steroids are synthesized in
peripheral target tissues from inactive steroid precursors and, in adult men, approximately …

In women and men, an important proportion of estrogens and androgens are synthesized
locally at their site of action in peripheral target tissues. This new field of endocrinology has …

17β-Hydroxysteroid dehydrogenase (17β-HSD) controls the last step in the formation of all
androgens and all estrogens. This crucial role of 17β-HSD is performed by at least five 17β …

17β-hydroxysteroid dehydrogenase (17β-HSD) controls the last step in the formation of all
androgens and all estrogens. At least six 17β-HSD isoenzymes have been identified. The …

Enzymes with 17β-hydroxysteroid dehydrogenase (17β-HSD) activity catalyse reactions
between the low-active female sex steroid, estrone, and the more potent estradiol, for …

Androgens and estrogens are not only synthesized in the gonads but also in peripheral
target tissues. Accordingly, recent molecular cloning has allowed us to identify multiple types …

In addition to the classical steroidogenic tissues, namely the ovaries, testes, adrenals and
placenta, a large series of human peripheral tissues possess all the enzymatic systems …

17β-Hydroxysteroid dehydrogenases (17HSDs) catalyze the interconversions between high-
activity 17β-hydroxysteroids and low-activity 17-ketosteroids. Several distinct 17HSD …

Primates are unique in having adrenals that secrete large amounts of the precursor sex
steroids (PSS) dehydroepiandrosterone (DHEA) and especially DHEA-sulfate. The adrenal …

The interconversion of estrone (E1) and 17β-estradiol (E2), androstenedione (4-ene-dione)
and testosterone (T), as well as dehydroepiandrosterone and androst-5-ene-3β, 17β-diol is …