Alpha-fetoprotein: Immunomodulation in autoimmune diseases during pregnancy and puerperium stages

GJ Mizejewski - GSC Biological and Pharmaceutical Sciences, 2022 - gsconlinepress.com
Alpha-fetoprotein (AFP) has long been associated with regulation and modulation of the
immune system in a variety of mammals. In the last several decades, AFP has been linked to …

More than a tumor marker… a potential role for alpha-feto protein in inflammatory bowel disease

EA Linson, SB Hanauer - Inflammatory bowel diseases, 2019 - academic.oup.com
Background Human alpha-fetoprotein (hAFP) is a glycoprotein derived from the gut
entoderm and expressed sequentially by cells of the yolk sac, fetal liver, and gastrointestinal …

[PDF][PDF] Alpha-Fetoprotein as an Immunoregulator and Immune Response Modifier: Historical Background and Current Update

GJ Mizejewski - Journal of Immunology Research & Reports. SRC …, 2022 - researchgate.net
The various immunological roles of human alpha-fetoprotein (HAFP) and its correlation with
hepatomas, ie, hepatocellular carcinomas (HCCs), are not always addressed together in the …

Evidence that immunosuppression is an intrinsic property of the alpha-fetoprotein molecule

DJ Semeniuk, R Boismenu, J Tam… - … of Proteins and …, 1995 - Springer
Among the proteins that comprise the albumin family, alpha-fetoprotein (AFP) is the only
member which exhibits immunoregulatory properties. However, some investigations have …

[HTML][HTML] Alpha-fetoprotein as a Shuttle for Medicines

VN Pak - pharmafocusasia.com
Alpha-fetoprotein (AFP) delivers ligands to monocytes/macrophages that regulate the
immune system activity. AFP or AFP-drugs can be used to treat autoimmune diseases, while …

[PDF][PDF] Alpha-fetoprotein (AFP) and inflammation: is AFP an acute and/or chronic phase reactant

GJ Mizejewski - Journal of Hematology & Thromboembolic Diseases, 2015 - Citeseer
Even though alpha-fetoprotein has long been implicated with inflammation during
pregnancy and adult liver dysfunction, the literature lacks a review of such a relationship …

Human α-fetoprotein (AFP) causes a selective down regulation of monocyte MHC class II molecules without altering other induced or noninduced monocyte markers …

K Laan-Pütsep, H Wigzell, P Cotran, M Gidlund - Cellular immunology, 1991 - Elsevier
Human α-fetoprotein (AFP) purified from human amniotic fluid was investigated for its effect
on human monocytoid cell lines, including U 937 cells with established subclones. The …

Alpha-fetoprotein-mediated immune tolerance and its reversal

VN Pak, NN Belyaev - Alpha-fetoprotein: functions and clinical …, 2016 - elibrary.ru
Alpha-fetoprotein (AFP) serves as a shuttle delivery protein to the AFP receptorpositive
embryo and cancer cells. By delivering nutrients through receptor-mediated endocytosis …

Immuno-suppressive effect of human alphafetoprotein: a cross species study

M Chakraborty, C Mandal… - Immunological …, 1993 - Taylor & Francis
Alphafetoprotein (AFP) is the major serum protein of fetal life in human and other
mammalian species. The phylogenetical concervatism of AFP demonstrated by extensive …

[PDF][PDF] Alpha-Fetoprotein as a Biomarker in Immunodeficiency Diseases: Relevance to Ataxia Telangiectasia and Related Disorders. J Immunodefic Disor 3: 1

GJ Mizejewski - of, 2014 - researchgate.net
Human Alpha-fetoprotein (AFP) involvement as a biomarker in immunodeficiency disorders
(IDD) has received little attention in the biomedical literature due to the recent focus on AFP …