Background—The present study examined whether transplantation of adherent bone
marrow–derived stem cells, termed pMultistem, induces neovascularization and …

Preclinical and clinical studies have demonstrated that stem cell transplantation can improve
the left ventricular (LV) contractile performance, yet the underlying mechanisms remain …

Progressive contractile dysfunction of viable myocardium that surrounds a large infarct leads
to heart failure following acute myocardial infarction (AMI). Experimental evidence indicates …

Cell transplantation is an emerging therapy for treating post-infarction heart failure. Although
the paracrine effect has been proposed to be an important mechanism for the therapeutic …

Rationale: The mechanism by which endogenous progenitor cells contribute to functional
and beneficial effects in stem cell therapy remains unknown. Objective: Utilizing a novel 31P …

OBJECTIVE: Stem cell therapy can facilitate cardiac repair in infarcted myocardium, but the
optimal cell type remains uncertain. We conducted a randomized, blind, and placebo …

Background—Using a swine model of postinfarction left ventricle (LV) remodeling, we
investigated marrow-derived, multipotent progenitor cell (MPC) transplantation into hearts …

Background—Experimental studies suggest that transplantation of blood-derived or bone
marrow–derived progenitor cells beneficially affects postinfarction remodeling. The safety …

Objectives: We compared biological repair after acute myocardial infarction (AMI) with
selected porcine progenitor cell populations. Background: Cell types and mechanisms …

In this study, we hypothesized that bone marrow stem cells (BMSCs) protect ischemic
myocardium through paracrine effects that can be further augmented with preconditioning. In …