Crosstalk mechanisms have not been studied as thoroughly as individual signaling
pathways. We exploit experimental and computational approaches to reveal how a …

Background Cellular response to external stimuli requires propagation of corresponding
signals through molecular signaling pathways. However, signaling pathways are not …

Insulin regulates an essential conserved signaling pathway affecting growth, proliferation,
and metabolism. To expand our understanding of the insulin pathway, we combine …

The response to insulin is impaired in type 2 diabetes. Much information is available about
insulin signaling, but understanding of the cellular mechanisms causing impaired signaling …

Cellular signal transduction is a complex process involving protein-protein interactions
(PPIs) that transmit information. For example, signals from the plasma membrane may be …

Although it is appreciated that canonical signal‐transduction pathways represent dominant
modes of regulation embedded in larger interaction networks, relatively little has been done …

Insulin and other hormones control target cells through a network of signal-mediating
molecules. Such networks are extremely complex due to multiple feedback loops in …

Insulin and IGF (insulin‐like growth factor) signaling integrates the storage and release of
nutrients with animal growth during development and throughout adult life. It is essential for …

The phosphoinositide 3-kinase (PI3K)-Akt network is tightly controlled by feedback
mechanisms that regulate signal flow and ensure signal fidelity. A rapid overshoot in insulin …

Feedback loops play a key role in the regulation of the complex interactions in signal
transduction networks. By studying the network of interactions among the biomolecules …