Background: Selenium and coenzyme Q10 (SeQ10) possess antioxidant and anti-
inflammatory properties, potentially mediated via Sirtuin1 (SIRT1). We aimed to investigate …

The development of atherosclerosis is a complex, multi-step process, which is at least in part
controlled by the functional state of the vascular endothelium. It is generally believed that the …

Coronary artery disease (CAD) is the primary critical cardiovascular event. Endothelial cell
and monocyte dysfunction with subsequent extravagant inflammation are the main causes of …

Background Selenium and coenzyme Q10 is essential for important cellular functions. A low
selenium intake is reported from many European countries, and the endogenous coenzyme …

Accumulating evidence indicates that oxidative stress can occur through overproduction of
reactive oxygen species (ROS) and/or reduced anti-oxidant potentials under …

Abstract Sirtuin 6 (SIRT6) is a member of the sirtuin family NAD+-dependent deacetylases
with multiple roles in controlling organism homeostasis, lifespan, and diseases. Due to its …

Purpose Selenium and coenzyme Q10 have synergistic antioxidant functions. In a four-year
supplemental trial in elderly Swedes with a low selenium status, we found improved cardiac …

Aim: Silencing information regulator (SirT1), a NAD-dependent histone deacetylase, is an
essential mediator of longevity in normal cells by calorie restriction. SirT1 has many …

Significance: Oxidative stress represents the common hallmark of pathological conditions
associated with cardiovascular disease (CVD), including atherosclerosis, heart failure …

Abstract Purpose of Review The purpose of this review is to summarize the most recent
findings investigating the impact of several natural sirtuin (SIRT) activators, particularly …